Força de compressão e umidade no perfil de dissolução da hidroclorotiazida

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorFaculdade de Ciências da Saúde Curso de Farmácia
dc.date.accessioned2014-05-27T11:21:48Z
dc.date.accessioned2022-10-05T18:00:28Z
dc.date.available2014-05-27T11:21:48Z
dc.date.available2022-10-05T18:00:28Z
dc.date.created2014-05-27T11:21:48Z
dc.date.issued2006-01-01
dc.identifierActa Farmaceutica Bonaerense, v. 25, n. 1, p. 104-107, 2006.
dc.identifier0326-2383
dc.identifierhttp://hdl.handle.net/11449/68750
dc.identifier2-s2.0-33744470123
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3918268
dc.description.abstractThe aim of this work was to evaluate the influence of compression force and humidity in the dissolution profile of tablets formulation. As hidroclorotyiazide presents real problems of bioavailability, it was incorporate as standard drug in a formulation of tablets to study the mechanical resistance, time of disintegration and dissolution profile in function of humidity and compression force. The time of disintegration was not affected by the compression force, but it was influenced by humidity. The dissolution profile was altered by the compression force and for the humidity as well. Both factors can alter the bioavailability of drugs dispensed in the form of tablets.
dc.languagepor
dc.relationActa Farmaceutica Bonaerense
dc.relation0.401
dc.relation0,152
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectDisintegration
dc.subjectDissolution profile
dc.subjectTablets
dc.subjecthydrochlorothiazide
dc.subjectcompressive strength
dc.subjectdissolution
dc.subjectdrug bioavailability
dc.subjectforce
dc.subjecthumidity
dc.subjecttablet formulation
dc.titleForça de compressão e umidade no perfil de dissolução da hidroclorotiazida
dc.typeArtigo


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