Artigo
New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis
Fecha
2005-11-01Registro en:
Journal of the Brazilian Chemical Society, v. 16, n. 6 B, p. 1463-1466, 2005.
0103-5053
10.1590/S0103-50532005000800029
S0103-50532005000800029
WOS:000234078700029
2-s2.0-30844445632
2-s2.0-30844445632.pdf
0037579054083160
4484083685251673
0000-0001-7616-9652
Autor
Universidade Estadual Paulista (Unesp)
Universidade Federal de Lavras (UFLA)
Universidade Estadual de Campinas (UNICAMP)
Instituto de Botânica
Universidade de São Paulo (USP)
Resumen
Two new metabolites, ethyl 2,4-dihydroxy-5,6-dimethylbenzoate (1) and phomopsilactone (2) were isolated from Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures were elucidated by 1D and 2D NMR, MS and IR spectral data. Compounds 1 and 2 displayed strong antifungal activity against the phytopatogenic fungi Cladosporium cladosporioides and C. sphaerospermum, as well as cytotoxicity against human cervical tumor cell line (HeLa), in in vitro assays. ©2005 Sociedade Brasileira de Química.