Evaluation of Strychnos pseudoquina St. Hil. leaves extract on gastrointestinal activity in mice

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-27T11:21:24Z
dc.date.accessioned2022-10-05T17:57:20Z
dc.date.available2014-05-27T11:21:24Z
dc.date.available2022-10-05T17:57:20Z
dc.date.created2014-05-27T11:21:24Z
dc.date.issued2005-08-01
dc.identifierChemical and Pharmaceutical Bulletin, v. 53, n. 8, p. 881-885, 2005.
dc.identifier0009-2363
dc.identifierhttp://hdl.handle.net/11449/68357
dc.identifier10.1248/cpb.53.881
dc.identifierWOS:000231320700002
dc.identifier2-s2.0-24944567759
dc.identifier3814504901386844
dc.identifier0000-0002-8645-3777
dc.identifier0000-0003-3032-2556
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3917905
dc.description.abstractStrychnos pseudoquina St. Hil. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects. © 2005 Pharmaceutical Society of Japan.
dc.languageeng
dc.relationChemical and Pharmaceutical Bulletin
dc.relation1.258
dc.relation0,364
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectAlkaloid
dc.subjectAntiulcer activity
dc.subjectStrychnos pseudoquina
dc.subjectToxic activity
dc.subjectpiroxicam
dc.subjectplant extract
dc.subjectstrychnos pseudoquina extract
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectconcentration response
dc.subjectcontrolled study
dc.subjectdrug dose regimen
dc.subjectdrug effect
dc.subjectdrug isolation
dc.subjectdrug screening
dc.subjectin vivo study
dc.subjectmale
dc.subjectmedicinal plant
dc.subjectmortality
dc.subjectmouse
dc.subjectnonhuman
dc.subjectphytochemistry
dc.subjectplant leaf
dc.subjectstomach mucosa
dc.subjectstomach protection
dc.subjectstomach ulcer
dc.subjectstrychnos pseudoquina
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectDrug Evaluation, Preclinical
dc.subjectGastric Mucosa
dc.subjectMice
dc.subjectPlant Extracts
dc.subjectPlant Leaves
dc.subjectStomach Ulcer
dc.subjectStrychnos
dc.titleEvaluation of Strychnos pseudoquina St. Hil. leaves extract on gastrointestinal activity in mice
dc.typeArtigo


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