Proteinase-activated receptor-2 (PAR2) agonist causes periodontitis in rats

dc.contributorUniversity of Calgary, Calgary
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:16Z
dc.date.accessioned2022-10-05T17:55:43Z
dc.date.available2014-05-27T11:21:16Z
dc.date.available2022-10-05T17:55:43Z
dc.date.created2014-05-27T11:21:16Z
dc.date.issued2005-02-01
dc.identifierJournal of Dental Research, v. 84, n. 2, p. 154-159, 2005.
dc.identifier0022-0345
dc.identifierhttp://hdl.handle.net/11449/68126
dc.identifier10.1177/154405910508400209
dc.identifierWOS:000226834200009
dc.identifier2-s2.0-15544371471
dc.identifier2640929291808415
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3917706
dc.description.abstractProteinase-activated receptor-2 (PAR2) is a G-protein-coupled receptor that mediates cellular responses to extracellular proteinases. Since PAR2 is expressed by oral epithelial cells, osteoblasts, and gingival fibroblasts, where its activation releases interleukin-8, we hypothesized that PAR2 activation may participate in periodontal disease in vivo. We investigated the role of PAR2 activation in periodontal disease in rats. Radiographic and enzymatic (myeloperoxidase) analysis revealed that topical application of PAR2 agonist causes periodontitis but also exacerbates existing periodontitis, leading to significant alveolar bone loss and gingival granulocyte infiltration. Inhibition of matrix metalloproteinase (MMP) and cyclo-oxygenase (COX) decreased PAR2 agonist-induced periodontitis. More specifically, the overexpression of COX-1, COX-2, MMP-2, and MMP-9 in gingival tissues suggests that they are involved in PAR 2-induced periodontitis. In conclusion, PAR2 agonist causes periodontitis in rats through a mechanism involving prostaglandin release and MMP activation. Inhibition of PAR2 may represent a novel approach to modulate host response in periodontitis.
dc.languageeng
dc.relationJournal of Dental Research
dc.relation5.380
dc.relation2,302
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectAlveolar bone loss
dc.subjectCyclo-oxygenase
dc.subjectInflammation
dc.subjectMatrix metalloproteinase
dc.subjectPeriodontitis
dc.subjectProteinase-activated receptor-2
dc.subjectenzyme inhibitor
dc.subjectmatrix metalloproteinase
dc.subjectoligopeptide
dc.subjectprostaglandin synthase
dc.subjectproteinase activated receptor 2
dc.subjectseryl leucyl isoleucyl glycyl arginyl leucinamide
dc.subjectseryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide
dc.subjectanalysis of variance
dc.subjectanimal
dc.subjectchemically induced disorder
dc.subjectcomparative study
dc.subjectdrug effect
dc.subjectdrug potentiation
dc.subjectgingiva
dc.subjectgranulocyte
dc.subjectimmunology
dc.subjectmale
dc.subjectmetabolism
dc.subjectosteolysis
dc.subjectperiodontitis
dc.subjectrandomization
dc.subjectrat
dc.subjectWistar rat
dc.subjectAlveolar Bone Loss
dc.subjectAnalysis of Variance
dc.subjectAnimals
dc.subjectEnzyme Inhibitors
dc.subjectGingiva
dc.subjectGranulocytes
dc.subjectMale
dc.subjectMatrix Metalloproteinases
dc.subjectOligopeptides
dc.subjectProstaglandin-Endoperoxide Synthases
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptor, PAR-2
dc.titleProteinase-activated receptor-2 (PAR2) agonist causes periodontitis in rats
dc.typeArtigo


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