dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:19:43Z
dc.date.accessioned2022-10-05T17:38:41Z
dc.date.available2014-05-27T11:19:43Z
dc.date.available2022-10-05T17:38:41Z
dc.date.created2014-05-27T11:19:43Z
dc.date.issued1999-03-15
dc.identifierBrain Research Bulletin, v. 48, n. 5, p. 521-525, 1999.
dc.identifier0361-9230
dc.identifierhttp://hdl.handle.net/11449/65741
dc.identifier10.1016/S0361-9230(99)00032-5
dc.identifierWOS:000080487800008
dc.identifier2-s2.0-2542509105
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3915626
dc.description.abstractThe subfornical organ (SFO) and the lateral hypothalamus (LH) have been shown to be important for the central action of angiotensin II (ANG II) on water and salt regulation. Several anatomical findings have demonstrated neural connections between the SFO and the LH. The present experiments were conducted to investigate the role of the α-adrenergic antagonists and agonists injected into the LH on the water and salt intake elicited by injections of ANG II into the SFO. Prazosin (an α1-adrenergic antagonist) injected into the LH increased the salt ingestion, whereas yohimbine (an α2-adrenergic antagonist) and propranolol (a β-adrenergic antagonist) antagonized the salt ingestion induced by administration of ANG II into the SFO. Previous administration of clonidine (an α2-adrenergic agonist) or noradrenaline into the LH increased, whereas pretreatment with phenylephrine decreased the sodium intake induced by injection of ANG II into the SFO. Previous treatment with prazosin and propranolol reduced the water intake induced by ANG II. Phenylephrine increased the dipsogenic responses produced by ANG II, whereas previous treatment with clonidine injected into the LH reduced the water intake induced by ANG II administration into the SFO. The LH involvement with SFO on the excitatory and inhibitory mechanisms related to water and sodium intake is suggested.
dc.languageeng
dc.relationBrain Research Bulletin
dc.relation3.440
dc.relation1,398
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectAdrenergic agonists
dc.subjectAdrenergic antagonists
dc.subjectLateral hypothalamus
dc.subjectSodium intake
dc.subjectSubfornical organ
dc.subjectWater intake
dc.subjectadrenalin
dc.subjectadrenergic receptor stimulating agent
dc.subjectprazosin
dc.subjectpropranolol
dc.subjectyohimbine
dc.subjectanimal experiment
dc.subjectdrug effect
dc.subjectfluid balance
dc.subjectfluid intake
dc.subjecthypothalamus
dc.subjectmale
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectsodium intake
dc.subjectsubfornical organ
dc.subjectAdrenergic alpha-Agonists
dc.subjectAdrenergic alpha-Antagonists
dc.subjectAngiotensin II
dc.subjectAnimals
dc.subjectDrinking
dc.subjectHypothalamic Area, Lateral
dc.subjectMale
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectReceptors, Adrenergic, alpha
dc.subjectSodium Chloride, Dietary
dc.subjectSubfornical Organ
dc.subjectWater-Electrolyte Balance
dc.titleEffects of the alpha antagonists and agonists injected into the lateral hypothalamus on the water and sodium intake induced by angiotensin II injection into the subfornical organ
dc.typeArtigo


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