Bioactive guanidine alkaloids from Pterogyne nitens

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorVIRGINIA POLYTECH INST & STATE UNIV
dc.date.accessioned2014-05-27T11:18:02Z
dc.date.accessioned2022-10-05T17:30:46Z
dc.date.available2014-05-27T11:18:02Z
dc.date.available2022-10-05T17:30:46Z
dc.date.created2014-05-27T11:18:02Z
dc.date.issued1995-12-01
dc.identifierJournal of Natural Products, v. 58, n. 11, p. 1683-1688, 1995.
dc.identifier0163-3864
dc.identifierhttp://hdl.handle.net/11449/64664
dc.identifier10.1021/np50125a006
dc.identifierWOS:A1995TQ55100006
dc.identifier2-s2.0-0029610979
dc.identifier4484083685251673
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3914673
dc.description.abstractBioactivity-guided fractionation of a methanolic CHCl 3 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C [5], all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC 12=9.3-20.0 μg/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B 1 cells (IC 50=8.5-13.0 μg/ml).
dc.languageeng
dc.relationJournal of Natural Products
dc.relation3.885
dc.relation1,368
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectguanidine derivative
dc.subjectnitensidine
dc.subjectpterogynidine
dc.subjectpterogynine
dc.subjectunclassified drug
dc.subjectantineoplastic activity
dc.subjectbioassay
dc.subjectcarbon nuclear magnetic resonance
dc.subjectcytotoxicity
dc.subjectdna repair
dc.subjectdrug activity
dc.subjectdrug isolation
dc.subjectdrug structure
dc.subjectproton nuclear magnetic resonance
dc.titleBioactive guanidine alkaloids from Pterogyne nitens
dc.typeArtigo


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