Artigo
OBTENCAO DE MESALAZINA (5-ASA) POR CARBOXILACAO DE P-AMINOFENOL
Fecha
1995-01-01Registro en:
Revista de Ciencias Farmaceuticas, v. 16, p. 105-110.
0101-3793
2-s2.0-0028887010
9734333607975413
0000-0003-4141-0455
Autor
Universidade Estadual Paulista (Unesp)
Resumen
The 5-aminosalicylic acid is usually prepared: 1. by the reduction of the azodye from diazotized aniline and salicylic acid and the posterior reduction of the formed compound; 2. for carboxylation with carbon dioxide under high pressure of p-aminophenol. Both do not present high yield, but the carboxylation process of p-aminophenol can easily be used and can reduce the obtainment process of 3 steps to only 2. Another advantage of this process is the fact that the product is produced without contaminants, because only one solid reagent (p-aminophenol) and the agent of carboxylation (CO2) is used.