Opiate activation suppresses the drinking, pressor and natriuretic responses induced by cholinergic stimulation of the medial septal area

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T11:17:28Z
dc.date.accessioned2022-10-05T17:27:17Z
dc.date.available2014-05-27T11:17:28Z
dc.date.available2022-10-05T17:27:17Z
dc.date.created2014-05-27T11:17:28Z
dc.date.issued1992-02-01
dc.identifierBrain Research Bulletin, v. 28, n. 2, p. 155-160, 1992.
dc.identifier0361-9230
dc.identifierhttp://hdl.handle.net/11449/64222
dc.identifier10.1016/0361-9230(92)90174-V
dc.identifier2-s2.0-0026500743
dc.identifier1023597870118105
dc.identifier6551236936295697
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3914332
dc.description.abstractThe present study investigates the participation and interaction between cholinergic and opiate receptors of the medial septal area (MSA) in the regulation of Na+, K+ and water excretion, drinking and blood pressure regulation. Male Holtzman rats were implanted with stainless steel cannulae opening into the MSA. Na+, K+ and water excretion, water intake and blood pressure were measured after injection of carbachol (cholinergic agonist), FK-33824 (an opiate agonist) + carbachol or naloxone (an opiate antagonist) + carbachol into MSA. Carbachol (0.5 or 2.0 nmol) induced an increase in Na+ and K+ excretion, water intake and blood pressure and reduced the urinary volume. FK-33824 reduced the urinary volume and Na+ and K+ excretion. Previous injection of FK-33824 (100 ng) into the MSA blocked the increases in Na+ and K+ excretion, water intake and blood pressure induced by carbachol. Naloxone (10 μg) produced no changes in the effect of 2.0 nmol carbachol, but potentiated the natriuretic effect induced by 0.5 nmol dose of carbachol. These data show an inhibitory effect of opiate receptors on the changes in cardiovascular, fluid and electrolyte balance induced by cholinergic stimulation of the MSA in rats. © 1992.
dc.languageeng
dc.relationBrain Research Bulletin
dc.relation3.440
dc.relation1,398
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectCarbacholl
dc.subjectCardiovascular responses
dc.subjectElectrolyte excretion
dc.subjectOpiates
dc.subjectSeptal area
dc.subjectcarbachol
dc.subjectcholinergic receptor stimulating agent
dc.subjectenkephalin[2 dextro alanine 4 methylphenylalanine 5 methioninol sulfoxide]
dc.subjectnaloxone
dc.subjectopiate agonist
dc.subjectopiate antagonist
dc.subjectopiate receptor
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectblood pressure
dc.subjectcontrolled study
dc.subjectdrinking
dc.subjectelectrolyte excretion
dc.subjectintracerebral drug administration
dc.subjectmale
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectseptum nucleus
dc.subjectAnalysis of Variance
dc.subjectAnimal
dc.subjectBlood Pressure
dc.subjectBrain
dc.subjectCarbachol
dc.subjectDiuresis
dc.subjectDrinking Behavior
dc.subjectDrug Interactions
dc.subjectFK 33-824
dc.subjectHeart Rate
dc.subjectMale
dc.subjectNaloxone
dc.subjectNatriuresis
dc.subjectRats
dc.subjectReference Values
dc.subjectSupport, Non-U.S. Gov't
dc.titleOpiate activation suppresses the drinking, pressor and natriuretic responses induced by cholinergic stimulation of the medial septal area
dc.typeArtigo


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