dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorSanta Casa de Londrina Hosp
dc.contributorBrigham & Womens Hosp
dc.contributorUniversidade Federal do Rio Grande do Sul (UFRGS)
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.contributorStanford Univ
dc.date.accessioned2014-05-20T15:33:33Z
dc.date.accessioned2022-10-05T17:16:02Z
dc.date.available2014-05-20T15:33:33Z
dc.date.available2022-10-05T17:16:02Z
dc.date.created2014-05-20T15:33:33Z
dc.date.issued2010-12-01
dc.identifierNeurological Research. Leeds: Maney Publishing, v. 32, n. 10, p. 1060-1071, 2010.
dc.identifier0161-6412
dc.identifierhttp://hdl.handle.net/11449/42138
dc.identifier10.1179/016164110X12670144737855
dc.identifierWOS:000283422300008
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3913008
dc.description.abstractObjective: The present article presents an overview of the literature, and analyses the methods and the primary questions related to assessment of proliferation index using the Ki-67/MIB-1 labeling index in pituitary adenomas. Although atypical adenomas are characterized by their atypical morphological features by an elevated mitotic index, a Ki-67 (MIB-1) labeling index greater than 3% and extensive nuclear staining for p53, use of the proliferation index (LI) of pituitary adenomas in assessing the degree of tumor aggressiveness is a controversial topic in the literature, and there are disparate results involving many studies.Methods: A review of literature was carried out to correlate the role of Ki-67 LI and its correlation with clinical findings, tumor size, invasiveness, recurrence, adenoma subtype, adenoma doubling time, and pituitary carcinomas is addressed. Results: The prognosis cannot be predicted on the basis of the Ki-67 LI alone. Although there is no direct relation between Ki-67 LI and some of these variables and controversial data were found regarding some topics, our review justify the use of Ki-67 in the analysis of pituitary adenomas as an additional information for clinical decision.Conclusion: Although assessment of proliferative may be helpful in predicting subsequent tumor recurrence or invasiveness, there are many other important and as yet unidentified factors pituitary tumors. It is clear that further research is needed to clarify these molecular mechanisms to predict those with a potentially poor clinical outcome.
dc.languageeng
dc.publisherManey Publishing
dc.relationNeurological Research
dc.relation1.449
dc.relation0,592
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectPituitary adenomas
dc.subjectLabeling index
dc.subjectCell growth
dc.subjectInvasion
dc.subjectMIB-1
dc.subjectKi-67
dc.titleLabeling index in pituitary adenomas evaluated by means of MIB-1: is there a prognostic role? A critical review
dc.typeArtigo


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