dc.contributor | Faculdade de Medicina de São José do Rio Preto (FAMERP) | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Centro Universitário Rio Preto | |
dc.contributor | VETPAT | |
dc.date.accessioned | 2014-05-20T15:30:36Z | |
dc.date.accessioned | 2022-10-05T17:00:06Z | |
dc.date.available | 2014-05-20T15:30:36Z | |
dc.date.available | 2022-10-05T17:00:06Z | |
dc.date.created | 2014-05-20T15:30:36Z | |
dc.date.issued | 2008-04-01 | |
dc.identifier | Pesquisa Veterinaria Brasileira. Rio Janeiro: Revista Pesquisa Veterinaria Brasileira, v. 28, n. 4, p. 207-215, 2008. | |
dc.identifier | 0100-736X | |
dc.identifier | http://hdl.handle.net/11449/39938 | |
dc.identifier | S0100-736X2008000400003 | |
dc.identifier | WOS:000256955400003 | |
dc.identifier | S0100-736X2008000400003.pdf | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3910983 | |
dc.description.abstract | E-cadherin is a cell-cell adhesion molecule and low e-cadherin expression is related to invasiveness and may indicate a bad prognosis in mammary neoplasms. The expression of cell proliferation markers PCNA and especially Ki-67, has also proved to have a strong prognostic value in this tumor class. The expression of these markers was related to the clinical-pathological characteristics of 73 surgically removed mammary tumors in female dogs by immunohistochemistry. There was no statistical correlation between these markers and death by neoplasm, survival time and disease-free interval. However, the loss of e-cadherin expression and marked Ki-67 expression (p=0.016) were considered statistically significant for the diagnosis (p=0.032). When evaluated as independent factors, there was evidence of the relationship between the loss of e-cadherin expression and high PCNA expression with changes in the body status (divided into obese, normal and cachectic) of female dogs (p=0.030); there was also evidence of the relationship between pseudopregnancy and e-cadherin alone (p=0.021) and for ulceration and PCNA alone (p=0.035). The significant correlation between the markers expression and these well known prognostic factors used individually or in combination suggests their prognostic value in canine mammary tumors. | |
dc.language | spa | |
dc.publisher | Revista Pesquisa Veterinaria Brasileira | |
dc.relation | Pesquisa Veterinária Brasileira | |
dc.relation | 0.385 | |
dc.rights | Acesso aberto | |
dc.source | Web of Science | |
dc.subject | Canine | |
dc.subject | Dell proliferation marker | |
dc.subject | E-cadherin | |
dc.subject | Immunohistochemistry | |
dc.subject | Mammary neoplasm | |
dc.title | Immunohistochemical evaluation of Ki-67 and PCNA in canine mammary neoplasias: Correlation with prognostic factors and clinical outcome | |
dc.type | Artigo | |