dc.contributor | Instituto Butantan | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Univ Estadual Santa Cruz | |
dc.contributor | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor | Hiroshima Univ | |
dc.contributor | Tokushima Bunri Univ | |
dc.contributor | Josai Int Univ | |
dc.contributor | Natl Inst Biomed Innovat | |
dc.date.accessioned | 2014-05-20T15:28:53Z | |
dc.date.accessioned | 2022-10-05T16:51:21Z | |
dc.date.available | 2014-05-20T15:28:53Z | |
dc.date.available | 2022-10-05T16:51:21Z | |
dc.date.created | 2014-05-20T15:28:53Z | |
dc.date.issued | 2007-12-01 | |
dc.identifier | Peptides. New York: Elsevier B.V., v. 28, n. 12, p. 2320-2327, 2007. | |
dc.identifier | 0196-9781 | |
dc.identifier | http://hdl.handle.net/11449/38617 | |
dc.identifier | 10.1016/j.peptides.2007.09.017 | |
dc.identifier | WOS:000251698000009 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3909913 | |
dc.description.abstract | A novel peptide, decoralin, was isolated from the venom of the solitary eumenine wasp Oreumenes decoratus. its sequence, Ser-Leu-Leu-Ser-Leu-Ile-Arg-Lys-Leu-Ile-Thr, was determined by Edman degradation and corroborated by solid-phase synthesis. This sequence has the characteristic features of linear cationic a-helical peptides; rich in hydrophobic and basic amino acids with no disulfide bond, and accordingly, it can be predicted to adopt an amphipathic a-helix secondary structure. In fact, the CD spectra of decoralin in the presence of TFE or SDS showed a high a-helical conformation content. In a biological evaluation, decoralin exhibited a significant broad-spectrum antimicrobial activity, and moderate mast cell degranulation and leishmanicidal activities, but showed virtually no hemolytic activity. A synthetic analog with C-terminal amidation showed a much more potent activity in all the biological assays. (c) 2007 Elsevier B.V. All rights reserved. | |
dc.language | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation | Peptides | |
dc.relation | 2.851 | |
dc.relation | 1,001 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | decoralin | |
dc.subject | solitary wasp venom | |
dc.subject | cationic linear alpha-helical peptide | |
dc.subject | amphipathic alpha-helix structure | |
dc.subject | antimicrobial and leishmanicidal | |
dc.subject | activity | |
dc.title | Decoralin, a novel linear cationic alpha-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus | |
dc.type | Artigo | |