Influence of free amino acids on clavulanic acid production by Streptomyces clavuligerus in synthetic medium

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2014-05-20T15:27:25Z
dc.date.accessioned2022-10-05T16:42:53Z
dc.date.available2014-05-20T15:27:25Z
dc.date.available2022-10-05T16:42:53Z
dc.date.created2014-05-20T15:27:25Z
dc.date.issued2006-02-01
dc.identifierBrazilian Archives of Biology and Technology. Curitiba-Paraná: Inst Tecnologia Parana, v. 49, p. 173-179, 2006.
dc.identifier1516-8913
dc.identifierhttp://hdl.handle.net/11449/37406
dc.identifierWOS:000239655700024
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3908935
dc.description.abstractThe effect of nitrogen source on clavulanic acid production was investigated in shake flasks. Media containing asparagine plus one of several different amino acids or a combination of two amino acids was tested. The best result, ca. 180 mg/L clavulanic acid, CA, in 60 h, was obtained with the lysine-tyrosine pair In an aerated and agitated fermentor this medium led to CA concentrations of ca. 210 mg/L, a remarkable production for synthetic medium utilization. Amino acids analysis during cultivation indicated that, while asparagine was consumed rapidly, lysine and tyrosine were metabolized slowly, promoting CA production.
dc.languageeng
dc.publisherInst Tecnologia Parana
dc.relationBrazilian Archives of Biology and Technology
dc.relation0.676
dc.relation0,281
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectclavulanic acid
dc.subjectb-lactamase inhibitor
dc.subjectS. clavuligerus
dc.subjectsynthetic medium
dc.subjectamino acids
dc.titleInfluence of free amino acids on clavulanic acid production by Streptomyces clavuligerus in synthetic medium
dc.typeArtigo


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