Molecular models of protein kinase 6 from Plasmodium falciparum

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:27:21Z
dc.date.accessioned2022-10-05T16:42:34Z
dc.date.available2014-05-20T15:27:21Z
dc.date.available2022-10-05T16:42:34Z
dc.date.created2014-05-20T15:27:21Z
dc.date.issued2005-12-01
dc.identifierJournal of Molecular Modeling. New York: Springer, v. 12, n. 1, p. 42-48, 2005.
dc.identifier1610-2940
dc.identifierhttp://hdl.handle.net/11449/37353
dc.identifier10.1007/s00894-005-0002-1
dc.identifierWOS:000233482800006
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3908896
dc.description.abstractCyclin-dependent kinases (CDKs) have been identified as potential targets for development of drugs, mainly against cancer. These studies generated a vast library of chemical inhibitors of CDKs, and some of these molecules can also inhibit kinases identified in the Plasmodium falciparum genome. Here we describe structural models for Protein Kinase 6 from P. falciparum (PfPK6) complexed with Roscovitine and Olomoucine. These models show clear structural evidence for differences observed in the inhibition, and may help designing inhibitors for PfPK6 generating new potential drugs against malaria.
dc.languageeng
dc.publisherSpringer
dc.relationJournal of Molecular Modeling
dc.relation1.507
dc.relation0,360
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectkinases
dc.subjectbioinformatics
dc.subjectPlasmodium falciparum
dc.subjectRoscovitine
dc.subjectOlomoucine
dc.titleMolecular models of protein kinase 6 from Plasmodium falciparum
dc.typeArtigo


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