Use of spin label EPR spectra to monitor peptide chain aggregation inside resin beads.

Artigo

Fecha

1997-01-27

Registro en:

Tetrahedron Letters. Oxford: Pergamon-Elsevier B.V., v. 38, n. 4, p. 517-520, 1997.

0040-4039

http://hdl.handle.net/11449/37094

10.1016/S0040-4039(96)02363-5

WOS:A1997WD98800005

9424346762460416

5711182251641103

0000-0002-4767-0904

http://repositorioslatinoamericanos.uchile.cl/handle/2250/3908679

Autor

Universidade Estadual Paulista (Unesp)

Universidade de São Paulo (USP)

Institución

Universidade Paulista Júlio de Mesquita Filho (Brasil)

Resumen

An EPR approach to monitor peptide chain aggregation inside resin beads is introduced. Model low and highly peptide-loaded resins containing an aggregating sequence were labeled with a paramagnetic amino acid derivative and studied with regard to their solvation behavior in different solvent systems. For the first time in the peptide synthesis, EPR spectroscopic has allowed the detection of differentiated levels of peptide chain aggregation as a function of solvent and resin loading. (C) 1997, Elsevier B.V. Ltd. All rights reserved.

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