dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T15:26:34Z | |
dc.date.accessioned | 2022-10-05T16:38:46Z | |
dc.date.available | 2014-05-20T15:26:34Z | |
dc.date.available | 2022-10-05T16:38:46Z | |
dc.date.created | 2014-05-20T15:26:34Z | |
dc.date.issued | 1996-10-01 | |
dc.identifier | Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 60, n. 4, p. 1099-1104, 1996. | |
dc.identifier | 0031-9384 | |
dc.identifier | http://hdl.handle.net/11449/36725 | |
dc.identifier | 10.1016/0031-9384(96)00058-3 | |
dc.identifier | WOS:A1996VJ16800010 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3908399 | |
dc.description.abstract | Adult male rats (n = 5-7 per group) were water deprived for 24 h with only food available. Then they had access to water for 2 h. At the end of the 2 h, 1.5% NaCl was offered to the animals and the intake was measured for another 2 h. The rats drank an average of 9.8 +/- 3.0 ml/120 min of 1.5% NaCl; water intake during this time was negligible (not more than 1.0 ml/120 min). Captopril injected IP at the doses of 12 and 24 mg/kg induced 60-90% inhibition of the intake. Losartan or PD123319 injected ICV induced 50-80% inhibition of the intake. Losartan (80 nmol) inhibited the intake at a lower dose than PD123319 (160 nmol). Neither losartan nor PD123319 inhibited 10% sucrose intake. The inhibition of 1.5% NaCl intake was not related to alterations in arterial pressure. The results show that the antagonism of the renin-angiotensin system inhibits the 1.5% NaCl intake induced by water deprivation. The inhibition induced by the angiotensin II antagonists suggest that this peptide is important for the control of salt intake induced by water deprivation. | |
dc.language | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation | Physiology & Behavior | |
dc.relation | 2.517 | |
dc.relation | 1,088 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | water deprivation | |
dc.subject | salt intake | |
dc.subject | angiotensin | |
dc.subject | AT(1) and AT(2) receptors | |
dc.subject | captopril | |
dc.subject | losartan | |
dc.subject | PD123319 | |
dc.subject | blood pressure | |
dc.title | Antagonism of the renin-angiotensin system and water deprivation-induced NaCl intake in rats | |
dc.type | Artigo | |