dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:26:34Z
dc.date.accessioned2022-10-05T16:38:46Z
dc.date.available2014-05-20T15:26:34Z
dc.date.available2022-10-05T16:38:46Z
dc.date.created2014-05-20T15:26:34Z
dc.date.issued1996-10-01
dc.identifierPhysiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 60, n. 4, p. 1099-1104, 1996.
dc.identifier0031-9384
dc.identifierhttp://hdl.handle.net/11449/36725
dc.identifier10.1016/0031-9384(96)00058-3
dc.identifierWOS:A1996VJ16800010
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3908399
dc.description.abstractAdult male rats (n = 5-7 per group) were water deprived for 24 h with only food available. Then they had access to water for 2 h. At the end of the 2 h, 1.5% NaCl was offered to the animals and the intake was measured for another 2 h. The rats drank an average of 9.8 +/- 3.0 ml/120 min of 1.5% NaCl; water intake during this time was negligible (not more than 1.0 ml/120 min). Captopril injected IP at the doses of 12 and 24 mg/kg induced 60-90% inhibition of the intake. Losartan or PD123319 injected ICV induced 50-80% inhibition of the intake. Losartan (80 nmol) inhibited the intake at a lower dose than PD123319 (160 nmol). Neither losartan nor PD123319 inhibited 10% sucrose intake. The inhibition of 1.5% NaCl intake was not related to alterations in arterial pressure. The results show that the antagonism of the renin-angiotensin system inhibits the 1.5% NaCl intake induced by water deprivation. The inhibition induced by the angiotensin II antagonists suggest that this peptide is important for the control of salt intake induced by water deprivation.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationPhysiology & Behavior
dc.relation2.517
dc.relation1,088
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectwater deprivation
dc.subjectsalt intake
dc.subjectangiotensin
dc.subjectAT(1) and AT(2) receptors
dc.subjectcaptopril
dc.subjectlosartan
dc.subjectPD123319
dc.subjectblood pressure
dc.titleAntagonism of the renin-angiotensin system and water deprivation-induced NaCl intake in rats
dc.typeArtigo


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