SUPEROXIDE RADICAL AND TOXICITY OF ENVIRONMENTAL NICKEL EXPOSURE

dc.contributorINST SALUD CARLOS 3
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:26:29Z
dc.date.accessioned2022-10-05T16:38:18Z
dc.date.available2014-05-20T15:26:29Z
dc.date.available2022-10-05T16:38:18Z
dc.date.created2014-05-20T15:26:29Z
dc.date.issued1995-03-01
dc.identifierHuman & Experimental Toxicology. Basingstoke: Stockton Press, v. 14, n. 3, p. 248-251, 1995.
dc.identifier0144-5952
dc.identifierhttp://hdl.handle.net/11449/36647
dc.identifier10.1177/096032719501400303
dc.identifierWOS:A1995QQ39500004
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3908341
dc.description.abstractThree nickel compounds were tested for pancreatic, hepatic and osteogenic damage in rats by a single i.m. injection Ni++ (7 mg kg(-1)). The nickel induced biochemical alterations included significantly increased levels of serum alkaline phosphatase in rats with NiS (75%) and NiO (50%). Amylase and aspartate transaminase were also increased, and lipoperoxide was increased in rats with NiO (5.6-fold) and NiS (3.4-fold). No serum changes were observed with NiCl2. Daily injection of Cu-Zn superoxide dismutase (SOD) conjugated with polyethylene glycol prevented the serum level changes, indicating that superoxide radical is an important intermediate in toxicity of nickel insoluble compounds.
dc.languageeng
dc.publisherStockton Press
dc.relationHuman & Experimental Toxicology
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectNICKEL
dc.subjectSUPEROXIDE RADICAL
dc.subjectTOXICITY
dc.subjectSUPEROXIDE DISMUTASE
dc.subjectRATS
dc.titleSUPEROXIDE RADICAL AND TOXICITY OF ENVIRONMENTAL NICKEL EXPOSURE
dc.typeArtigo


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