Artigo
Antifungal constituents from roots of Virola surinamensis
Fecha
1999-05-01Registro en:
Phytochemistry. Oxford: Pergamon-Elsevier B.V., v. 51, n. 1, p. 29-33, 1999.
0031-9422
10.1016/S0031-9422(98)00709-2
WOS:000080384200006
Autor
Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
Resumen
Chromatographic fractionation of the dichloromethane extract from roots of Virola surinamensis yielded two new natural products, 3-epi-juruenolide C and 2'-hydroxy-7,4'-dimethoxyisoflavone, as well as various known steroids, lignans, isoflavones, flavonoids and diarylpropanes. of these, alpha,2'-dihydroxy-4,3'-dimethoxydihydrochal biochanin A and 2'-hydroxy-7,4'-dimethoxyisoflavone displayed antifungal activity against Cladosporium cladosporioides at a minimum amount of 5 mu g, whereas 7-hydroxyflavanone and 7-hydroxy-4'-methoxyisoflavone exhibited an antifungal activity 10-fold higher than the positive control Nystatin. (C) 1999 Elsevier B.V. Ltd. All rights reserved.