dc.contributor | Univ Utrecht | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Univ Athens | |
dc.contributor | Univ Pittsburgh | |
dc.contributor | Univ Oslo | |
dc.contributor | Univ Helsinki | |
dc.contributor | University of Rochester | |
dc.date.accessioned | 2014-05-20T15:25:24Z | |
dc.date.accessioned | 2022-10-05T16:33:15Z | |
dc.date.available | 2014-05-20T15:25:24Z | |
dc.date.available | 2022-10-05T16:33:15Z | |
dc.date.created | 2014-05-20T15:25:24Z | |
dc.date.issued | 2000-10-01 | |
dc.identifier | Metabolism-clinical and Experimental. Philadelphia: W B Saunders Co, v. 49, n. 10, p. 1318-1325, 2000. | |
dc.identifier | 0026-0495 | |
dc.identifier | http://hdl.handle.net/11449/35833 | |
dc.identifier | 10.1053/meta.2000.9526 | |
dc.identifier | WOS:000089861800013 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3907685 | |
dc.description.abstract | We performed hyperglycemic clamps in 283 nondiabetic Caucasians and, with multiple linear regression, determined the contribution of beta-cell function and tissue insulin sensitivity to variations in glycemia and insulinemia during oral glucose tolerance tests (OGTTs). Impaired glucose tolerance (IGT) subjects had reduced insulin sensitivity(P < .02) and beta-cell function (P < .0001). Normal glucose tolerance (NGT) subjects with first-degree type 2 diabetic relatives had reduced first and second phase insulin secretion (both, P < .05), but normal insulin sensitivity(P = .37). beta-Cell function and insulin sensitivity accounted for one fourth of the variability in glucose tolerance. Fasting plasma glucose in subjects with NGT (n = 185) was a function of both phases of insulin secretion and of insulin sensitivity tall, P < .05), whereas, in IGT subjects (n = 98), it was a function of first phase insulin secretion and insulin sensitivity(P < .01). Two-hour glycemia was a function of second phase secretion and insulin sensitivity (P < .01). Fasting and 2-hour plasma insulin levels were determined by insulin sensitivity land glycemia) in NGT subjects (P < .001), but by second phase secretion in IGT (P < .001). We conclude that beta-cell function is reduced in subjects with IGT; glycemia and insulinemia are not regulated by the same mechanisms in IGT and NGT; insulin sensitivity does not contribute to insulinemia in IGT; family history of diabetes influences beta-cell function, but not insulin sensitivity in Caucasians. Copyright (C) 2000 by W.B. Saunders Company. | |
dc.language | eng | |
dc.publisher | W B Saunders Co | |
dc.relation | Metabolism-clinical and Experimental | |
dc.relation | 5.963 | |
dc.relation | 2,285 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.title | Relative contributions of beta-cell function and tissue insulin sensitivity to fasting and postglucose-load glycemia | |
dc.type | Artigo | |