dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:21:17Z
dc.date.accessioned2022-10-05T16:10:13Z
dc.date.available2014-05-20T15:21:17Z
dc.date.available2022-10-05T16:10:13Z
dc.date.created2014-05-20T15:21:17Z
dc.date.issued1998-01-01
dc.identifierGeneral Pharmacology-the Vascular System. New York: Elsevier B.V., v. 30, n. 1, p. 79-83, 1998.
dc.identifier0306-3623
dc.identifierhttp://hdl.handle.net/11449/32449
dc.identifier10.1016/S0306-3623(97)00074-8
dc.identifierWOS:A1998YF52600012
dc.identifier5616488317690037
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3905005
dc.description.abstract1. The objective was to determine whether nitric oxide participates in stress adaptive responses. Acute stress (AS) decreased endothelium-dependent vasoconstriction to noradrenaline (NA) in rat aorta [control rat (CR) 3.90+/-0.18, n=22; AS 2.76+/-0.20, n=13; P<0.05].2. Chronic stress exposure previous to AS (CS) potentiated this effect [CS 1.93+/-0.19; n=9; P<0.05 related to CR, P<0.05 related to AS].3. Methylene blue and N-G monomethyl-L-arginine, but not indomethaein, restored the decreased aorta reactivity to NA. 4. No reactivity alteration was observed in aorta without endothelium either in both stress conditions or in the presence of inhibitors. These data show that the nitric oxide participates in stress responses. (C) 1998 Elsevier B.V.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationGeneral Pharmacology-the Vascular System
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectacute and chronic stress
dc.subjectendothelium
dc.subjectnitric oxide
dc.subjectreactivity of rat aorta
dc.subjectmethylene blue
dc.subjectL-NMMA
dc.titleDecreased endothelium-dependent vasoconstriction to noradrenaline in acute-stressed rats is potentiated by previous chronic stress: Nitric oxide involvement
dc.typeArtigo


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