Artigo
Carprofen and buprenorphine prevent hyperalgesia in a model of inflammatory pain in cats
Fecha
2007-12-01Registro en:
Research In Veterinary Science. Oxford: Elsevier B.V., v. 83, n. 3, p. 369-375, 2007.
0034-5288
10.1016/j.rvsc.2007.01.007
WOS:000250137000013
4473260410099623
0000-0001-5312-9076
Autor
Taylor Monroe Gravel Head Farm
Universidade Estadual Paulista (Unesp)
Resumen
A model of nociceptive threshold determination was developed for evaluation of NSAID analgesia in cats. In a crossover study, eight cats received carprofen (4 mg/kg), buprenorphine (0.01 mg/kg) or saline (0.3 ml) subcutaneously before intradermal kaolin injection on the antebrachium to induce mild inflammation. Pressure thresholds were measured at the injected site using blunt-ended pins advanced by manual inflation of a bladder within a bracelet. Bladder pressure was recorded as threshold (PT) at the behavioural end point. Baseline PT were recorded before kaolin injection (time 0). PT was measured at 2-10 h intervals for 52 h. PT below the lower 95% confidence interval (CI) of baseline values indicated hyperalgesia. After saline, hyperalgesia was detected from 2-6 h, 22-26 h, and at 30 and 36 h. After carprofen, PT remained within the 95% CI. After buprenorphine, PT remained within the 95% CI except at 2 h. Carprofen and to some extent buprenorphine, prevented inflammatory hyperalgesia. (C) 2007 Elsevier Ltd. All rights reserved.