dc.contributor | Jichi Med Sch | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Suntory Inst Bioorgan Res | |
dc.contributor | Tokyo Univ Agr | |
dc.contributor | Hiroshima Univ | |
dc.contributor | Tokyo Metropolitan Inst Neurosci | |
dc.date.accessioned | 2014-05-20T15:19:48Z | |
dc.date.accessioned | 2022-10-05T16:02:04Z | |
dc.date.available | 2014-05-20T15:19:48Z | |
dc.date.available | 2022-10-05T16:02:04Z | |
dc.date.created | 2014-05-20T15:19:48Z | |
dc.date.issued | 2000-05-05 | |
dc.identifier | Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 285, n. 1, p. 29-32, 2000. | |
dc.identifier | 0304-3940 | |
dc.identifier | http://hdl.handle.net/11449/31183 | |
dc.identifier | 10.1016/S0304-3940(00)01017-X | |
dc.identifier | WOS:000087088600008 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3903994 | |
dc.description.abstract | The structural specificity of alpha-PMTX, a novel peptide toxin derived from wasp venom has been studied on the neuromuscular synapse in the walking leg of the lobster. alpha-PMTX is known to induce repetitive action potentials in the presynaptic axon due to sodium channel inactivation. We synthesized 29 analogs of alpha-PMTX by substituting one or two amino acids and compared threshold concentrations of these mutant toxins for inducing repetitive action potentials. In 13 amino acid residues of alpha-PMTX, Arg-1, Lys-3 and Lys-12 regulate the toxic activity because substitution of these basic amino acid residues with other amino acid residues greatly changed the potency. Determining the structure-activity relationships of PMTXs will help clarifying the molecular mechanism of sodium channel inactivation. (C) 2000 Elsevier B.V. Ireland Ltd. All rights reserved. | |
dc.language | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation | Neuroscience Letters | |
dc.relation | 2.159 | |
dc.relation | 0,946 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | neurotoxin | |
dc.subject | sodium channel | |
dc.subject | inactivation | |
dc.subject | PMTX | |
dc.subject | neuromuscular synapse | |
dc.title | Molecular determinants of binding of a wasp toxin (PMTXs) and its analogs in the Na+ channels proteins | |
dc.type | Artigo | |