Caracterização do complexo de inclusão ropivacaína: β-ciclodextrina

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de Sorocaba (UNISO)
dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.contributorUniversidade de Parma
dc.date.accessioned2014-05-20T15:10:23Z
dc.date.accessioned2022-10-05T15:33:05Z
dc.date.available2014-05-20T15:10:23Z
dc.date.available2022-10-05T15:33:05Z
dc.date.created2014-05-20T15:10:23Z
dc.date.issued2007-10-01
dc.identifierQuímica Nova. Sociedade Brasileira de Química, v. 30, n. 5, p. 1203-1207, 2007.
dc.identifier0100-4042
dc.identifierhttp://hdl.handle.net/11449/27605
dc.identifier10.1590/S0100-40422007000500028
dc.identifierS0100-40422007000500028
dc.identifier2-s2.0-36148936330
dc.identifierS0100-40422007000500028.pdf
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3900514
dc.description.abstractCharacteriza of the inclusion complex ropivacaine: β-cyclodextrin. Ropivacaine (RVC) is a widely used local anesthetic. The complexation of RVC with β-cyclodextrin (β-CD) is of great interest for the development of more efficient local anesthetic formulations. The present work focuses on the characterization of the RVC:β-CD complex by nuclear magnetic resonance (NMR). The stoichiometry of the complex is 1:2 RVC:β-CD. DOSY-NMR shows that the association constant is 55.5 M-1. Longitudinal relaxation time results show that RVC changes its mobility in the presence of β-CD. This study is focused on the physicochemical characterization of inclusion complexes that are potentials options for pain treatment.
dc.languagepor
dc.publisherSociedade Brasileira de Química
dc.relationQuímica Nova
dc.relation0.646
dc.relation0,255
dc.rightsAcesso aberto
dc.sourceSciELO
dc.subjectropivacaine
dc.subjectcyclodextrin
dc.subjectNMR
dc.titleCaracterização do complexo de inclusão ropivacaína: β-ciclodextrina
dc.typeArtigo


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