dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T15:09:16Z | |
dc.date.accessioned | 2022-10-05T15:29:00Z | |
dc.date.available | 2014-05-20T15:09:16Z | |
dc.date.available | 2022-10-05T15:29:00Z | |
dc.date.created | 2014-05-20T15:09:16Z | |
dc.date.issued | 1991-01-01 | |
dc.identifier | Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 86, p. 47-50, 1991. | |
dc.identifier | 0074-0276 | |
dc.identifier | http://hdl.handle.net/11449/27164 | |
dc.identifier | 10.1590/S0074-02761991000600013 | |
dc.identifier | S0074-02761991000600013 | |
dc.identifier | S0074-02761991000600013.pdf | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3900081 | |
dc.description.abstract | Cancer development is a long-term multistep process which allows interventional measure before the clincial disease emerges. the detection of natural substances which can block the process of carcinogenesis is a important as the identification of anti-tumoral drugs since they might be used in chemoprevention of cancer in high-risk groups. In vivo rodent models of chemical caecinogenesis have been used to study plant-derived inhibitors of carcinofenesis such as indols, coumarins, isothiocyanates, flavones, phenols and allyl-sulfides. Since the standard in vivo rodent bioassay is prolonged and expensive, shorter reliable protocols are needed. Two in vivo medium-term protocols for evaluation of modifiers of carcinogenesis are presented, one related to liver and the other to bladder cancer. Both protocols use rats, last 8 and 36 weeks and are based on the two-step concept of carcinogenesis: initiation and promotion. The protocols use respectively the development of altered foci of hepatocytes expressing immunochistochemically the placental form of gluthation S-transferase and the appearence of pre-neoplastic urothelium and papillomas as the end-points. the use of these protocols for detection of plantpderived inhibitors of carcinogenesis appear warranted. | |
dc.language | eng | |
dc.publisher | Instituto Oswaldo Cruz, Ministério da Saúde | |
dc.relation | Memórias do Instituto Oswaldo Cruz | |
dc.relation | 2.833 | |
dc.relation | 1,172 | |
dc.rights | Acesso aberto | |
dc.source | SciELO | |
dc.subject | carcinogenesis | |
dc.subject | chemoprevention | |
dc.subject | bladder cancer | |
dc.subject | liver cancer | |
dc.subject | plant | |
dc.subject | derived inhibitors | |
dc.title | Medium-term protocols for in vivo evaluation of chemical modifiers of carcinogenesis | |
dc.type | Artigo | |