Triterpenes and antitubercular activity of Byrsonima crassa

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorInstituto Adolfo Lutz (IAL)
dc.date.accessioned2014-05-20T14:20:37Z
dc.date.accessioned2022-10-05T15:20:48Z
dc.date.available2014-05-20T14:20:37Z
dc.date.available2022-10-05T15:20:48Z
dc.date.created2014-05-20T14:20:37Z
dc.date.issued2008-01-01
dc.identifierQuímica Nova. Sociedade Brasileira de Química, v. 31, n. 7, p. 1719-1721, 2008.
dc.identifier0100-4042
dc.identifierhttp://hdl.handle.net/11449/26185
dc.identifier10.1590/S0100-40422008000700023
dc.identifierS0100-40422008000700023
dc.identifierWOS:000262432800023
dc.identifierS0100-40422008000700023.pdf
dc.identifier0000-0003-3032-2556
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3899203
dc.description.abstractWe evaluated the potential antitubercular activity of triterpenes obtained from leaves and bark of Byrsonima crassa. From chloroform extracts of the leaves, by bioassay-guided fractionation, we obtained mixtures of known triterpenes: α-amyrin, β-amyrin and their acetates, lupeol, oleanolic acid, ursolic acid and α-amyrinone. Tested against Mycobacterium tuberculosis, the triterpenes exhibited minimum inhibitory concentrations (MICs) of 31.25 - 312.25 µg/mL. β-amyrin and friedelin, isolated from the chloroform extract of bark, showed MICs of 312.25 and 125 µg/mL respectively. This is the first report of the identification and determination of the activity of B. crassa triterpenes against M. tuberculosis.
dc.languageeng
dc.publisherSociedade Brasileira de Química
dc.relationQuímica Nova
dc.relation0.646
dc.relation0,255
dc.rightsAcesso aberto
dc.sourceSciELO
dc.subjectByrsonima crassa
dc.subjectantitubercular activity
dc.subjecttriterpenes
dc.titleTriterpenes and antitubercular activity of Byrsonima crassa
dc.typeArtigo


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