dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Universidade Federal de São Carlos (UFSCar) | |
dc.date.accessioned | 2014-05-20T14:17:30Z | |
dc.date.accessioned | 2022-10-05T15:13:47Z | |
dc.date.available | 2014-05-20T14:17:30Z | |
dc.date.available | 2022-10-05T15:13:47Z | |
dc.date.created | 2014-05-20T14:17:30Z | |
dc.date.issued | 1998-12-01 | |
dc.identifier | Brazilian Journal of Chemical Engineering. Brazilian Society of Chemical Engineering, v. 15, n. 4, p. 320-325, 1998. | |
dc.identifier | 0104-6632 | |
dc.identifier | http://hdl.handle.net/11449/25245 | |
dc.identifier | 10.1590/S0104-66321998000400001 | |
dc.identifier | S0104-66321998000400001 | |
dc.identifier | 2-s2.0-0032313949 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3898365 | |
dc.description.abstract | Cephalosporin C, a b -lactam antibiotic, is the starting molecule for industrial production of semi-synthetic cephalosporins. The bioprocess for its production is carried out in batch stirred and aerated tank reactors utilizing strains of the filamentous fungus Cephalosporium acremonium. In this work a comparison was made between the processes of production of cephalosporin C in a conventional batch bioreactor, with synthetic medium containing glucose and sucrose, and in a fed-batch reactor at several flowrates of supplementary medium containing invert sucrose. In general, the fed-batch process was shown to be more efficient than the conventional batch one, and the process in which the lowest supplementation flowrate was used presented an antibiotic production significantly higher than those obtained under the other conditions. | |
dc.language | eng | |
dc.publisher | Brazilian Society of Chemical Engineering | |
dc.relation | Brazilian Journal of Chemical Engineering | |
dc.relation | 0.925 | |
dc.relation | 0,395 | |
dc.rights | Acesso aberto | |
dc.source | SciELO | |
dc.subject | Cephalosporium acremonium | |
dc.subject | invert sugar | |
dc.subject | cephalosporin C | |
dc.subject | fed batch | |
dc.title | Effect of the addition of invert sugar on the production of cephalosporin C in a fed-batch bioreactor | |
dc.type | Artigo | |