dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2014-05-20T14:17:30Z
dc.date.accessioned2022-10-05T15:13:47Z
dc.date.available2014-05-20T14:17:30Z
dc.date.available2022-10-05T15:13:47Z
dc.date.created2014-05-20T14:17:30Z
dc.date.issued1998-12-01
dc.identifierBrazilian Journal of Chemical Engineering. Brazilian Society of Chemical Engineering, v. 15, n. 4, p. 320-325, 1998.
dc.identifier0104-6632
dc.identifierhttp://hdl.handle.net/11449/25245
dc.identifier10.1590/S0104-66321998000400001
dc.identifierS0104-66321998000400001
dc.identifier2-s2.0-0032313949
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3898365
dc.description.abstractCephalosporin C, a b -lactam antibiotic, is the starting molecule for industrial production of semi-synthetic cephalosporins. The bioprocess for its production is carried out in batch stirred and aerated tank reactors utilizing strains of the filamentous fungus Cephalosporium acremonium. In this work a comparison was made between the processes of production of cephalosporin C in a conventional batch bioreactor, with synthetic medium containing glucose and sucrose, and in a fed-batch reactor at several flowrates of supplementary medium containing invert sucrose. In general, the fed-batch process was shown to be more efficient than the conventional batch one, and the process in which the lowest supplementation flowrate was used presented an antibiotic production significantly higher than those obtained under the other conditions.
dc.languageeng
dc.publisherBrazilian Society of Chemical Engineering
dc.relationBrazilian Journal of Chemical Engineering
dc.relation0.925
dc.relation0,395
dc.rightsAcesso aberto
dc.sourceSciELO
dc.subjectCephalosporium acremonium
dc.subjectinvert sugar
dc.subjectcephalosporin C
dc.subjectfed batch
dc.titleEffect of the addition of invert sugar on the production of cephalosporin C in a fed-batch bioreactor
dc.typeArtigo


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