dc.contributor | Sao Jose Rio Preto Med Sch | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Universidade de São Paulo (USP) | |
dc.date.accessioned | 2014-05-20T14:01:10Z | |
dc.date.accessioned | 2022-10-05T14:47:41Z | |
dc.date.available | 2014-05-20T14:01:10Z | |
dc.date.available | 2022-10-05T14:47:41Z | |
dc.date.created | 2014-05-20T14:01:10Z | |
dc.date.issued | 2011-01-01 | |
dc.identifier | Journal of Molecular Medicine-jmm. New York: Springer, v. 89, n. 1, p. 51-63, 2011. | |
dc.identifier | 0946-2716 | |
dc.identifier | http://hdl.handle.net/11449/21617 | |
dc.identifier | 10.1007/s00109-010-0684-4 | |
dc.identifier | WOS:000288363200007 | |
dc.identifier | 5102737730539655 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3895384 | |
dc.description.abstract | Inflammation is currently recognized as a key mechanism in the pathogenesis of renal ischemia-reperfusion (I/R) injury. The importance of infiltrating neutrophil, lymphocytes, and macrophage in this kind of injury has been assessed with conflicting results. Annexin 1 is a protein with potent neutrophil anti-migratory activity. In order to evaluate the effects of annexin A1 on renal I/R injury, uninephrectomized rats received annexin A1 mimetic peptide Ac2-26 (100 mu g) or vehicle before 30 min of renal artery clamping and were compared to sham surgery animals. Annexin A1 mimetic peptide granted a remarkable protection against I/R injury, preventing glomerular filtration rate and urinary osmolality decreases and acute tubular necrosis development. Annexin A1 infusion aborted neutrophil extravasation and attenuated macrophage infiltration but did not prevent tissue lymphocyte traffic. I/R increased annexin A1 expression (assessed by transmission electron microscopy) in renal epithelial cells, which was attenuated by exogenous annexin A1 infusion. Additionally, annexin A1 reduced I/R injury in isolated proximal tubules suspension. Annexin A1 protein afforded striking functional and structural protection against renal I/R. These results point to an important role of annexin A1 in the epithelial cells defense against I/R injury and indicate that neutrophils are key mediators for the development of tissue injury after renal I/R. If these results were confirmed in clinical studies, annexin A1 might emerge as an important tool to protect against I/R injury in renal transplantation and in vascular surgery. | |
dc.language | eng | |
dc.publisher | Springer | |
dc.relation | Journal of Molecular Medicine-jmm | |
dc.relation | 4.938 | |
dc.relation | 2,177 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Annexin A1 | |
dc.subject | Acute kidney injury | |
dc.subject | Ischemia/reperfusion injury | |
dc.subject | Kidney | |
dc.subject | Neutrophils | |
dc.subject | Acute tubular necrosis | |
dc.title | Annexin 1 mimetic peptide protects against renal ischemia/reperfusion injury in rats | |
dc.type | Artigo | |