dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Institute Butantan | |
dc.date.accessioned | 2014-05-20T13:54:38Z | |
dc.date.accessioned | 2022-10-05T14:32:38Z | |
dc.date.available | 2014-05-20T13:54:38Z | |
dc.date.available | 2022-10-05T14:32:38Z | |
dc.date.created | 2014-05-20T13:54:38Z | |
dc.date.issued | 2005-11-01 | |
dc.identifier | Peptides. New York: Elsevier B.V., v. 26, n. 11, p. 2157-2164, 2005. | |
dc.identifier | 0196-9781 | |
dc.identifier | http://hdl.handle.net/11449/19558 | |
dc.identifier | 10.1016/j.peptides.2005.04.026 | |
dc.identifier | WOS:000233373100016 | |
dc.identifier | 8302605179522059 | |
dc.identifier | 2901888624506535 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3893609 | |
dc.description.abstract | Two novel inflammatory peptides were isolated from the venom of the social wasp Polybia paulista. They had their molecular masses determined by ESI-MS and their primary sequences were elucidated by Edman degradation chemistry as:Polybia-MPI: I D W K K L L D A A K Q I L-NH2 (1654.09 Da),Polybia-CP: I L G T I L G L L K S L-NH2 (1239.73 Da).Both peptides were functionally characterized by using Wistar rat cells. Polybia-MPI is a mast cell lytic peptide, which causes no hemolysis to rat erythrocytes and presents chemotaxis for polymorphonucleated leukocytes (PMNL) and with potent antimicrobial action both against Gram-positive and Gram-negative bacteria. Polybia-CP was characterized as a chemotactic peptide for PMNL cells, presenting antimicrobial action against Gram-positive bacteria, but causing no hemolysis to rat erythrocytes and no mast cell degranulation activity at physiological concentrations. (c) 2005 Elsevier B.V. All rights reserved. | |
dc.language | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation | Peptides | |
dc.relation | 2.851 | |
dc.relation | 1,001 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Polybia paulista | |
dc.subject | hymenoptera insect | |
dc.subject | polycationic peptide | |
dc.subject | wasp venom | |
dc.subject | mastoparans | |
dc.subject | chemotactic peptides | |
dc.title | Structural and functional characterization of two novel peptide toxins isolated from the venom of the social wasp Polybia paulista | |
dc.type | Artigo | |