Artigo
Antineoplasic Drug Methotrexate Redox Mechanism Using a Glassy Carbon Electrode
Fecha
2012-04-01Registro en:
Electroanalysis. Weinheim: Wiley-v C H Verlag Gmbh, v. 24, n. 4, p. 917-923, 2012.
1040-0397
10.1002/elan.201100558
WOS:000302160000026
5216150705972509
Autor
Univ Coimbra
Universidade Estadual Paulista (Unesp)
Hosp Univ Coimbra
Resumen
Methotrexate (MTX) is an antimetabolite of folic acid indicated in the treatment of a variety of cancers. The electrochemical behaviour of MTX on a glassy carbon electrode was investigated. The MTX oxidation is a complex, pH-dependent, diffusion-controlled irreversible process and proceeds with the transfer of two electrons and two protons and the formation of one electroactive product, 7-hydroxymethotrexate that undergoes a reversible redox reaction. The MTX reduction is a pH-dependent, quasi-reversible process and involves the transfer of two electrons and two protons leading to the formation of an electroactive product.