dc.contributor | Universidade de São Paulo (USP) | |
dc.contributor | Boston University | |
dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:46:00Z | |
dc.date.accessioned | 2022-10-05T14:12:53Z | |
dc.date.available | 2014-05-20T13:46:00Z | |
dc.date.available | 2022-10-05T14:12:53Z | |
dc.date.created | 2014-05-20T13:46:00Z | |
dc.date.issued | 2011-01-01 | |
dc.identifier | Archives of Oral Biology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 56, n. 1, p. 41-47, 2011. | |
dc.identifier | 0003-9969 | |
dc.identifier | http://hdl.handle.net/11449/16238 | |
dc.identifier | 10.1016/j.archoralbio.2010.08.011 | |
dc.identifier | WOS:000286548400006 | |
dc.identifier | 2640929291808415 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3891295 | |
dc.description.abstract | Objective: In this study we have assessed the renal and cardiac consequences of ligature-induced periodontitis in both normotensive and nitric oxide (NO)-deficient (L-NAME-treated) hypertensive rats.Materials and methods: Oral L-NAME (or water) treatment was started two weeks prior to induction of periodontitis. Rats were sacrificed 3, 7 or 14 days after ligature placement, and alveolar bone loss was evaluated radiographically. Thiobarbituric reactive species (TBARS; a lipid peroxidation index), protein nitrotyrosine (NT; a marker of protein nitration) and myeloperoxidase activity (MPO; a neutrophil marker) were determined in the heart and kidney.Results: In NO-deficient hypertensive rats, periodontitis-induced alveolar bone loss was significantly diminished. In addition, periodontitis-induced cardiac NT elevation was completely prevented by L-NAME treatment. on the other hand L-NAME treatment enhanced MPO production in both heart and kidneys of rats with periodontitis. No changes due to periodontitis were observed in cardiac or renal TBARS content.Conclusions: In addition to mediating alveolar bone loss, NO contributes to systemic effects of periodontitis in the heart and kidney. (C) 2010 Elsevier Ltd. All rights reserved. | |
dc.language | eng | |
dc.publisher | Pergamon-Elsevier B.V. Ltd | |
dc.relation | Archives of Oral Biology | |
dc.relation | 2.050 | |
dc.relation | 0,752 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Periodontitis | |
dc.subject | Nitric oxide | |
dc.subject | Neutrophils | |
dc.subject | Nitrotyrosine | |
dc.subject | Lipid peroxidation | |
dc.subject | Heart | |
dc.subject | Kidney | |
dc.title | Local and cardiorenal effects of periodontitis in nitric oxide-deficient hypertensive rats | |
dc.type | Artigo | |