dc.contributorUniversidade de São Paulo (USP)
dc.contributorBoston University
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:46:00Z
dc.date.accessioned2022-10-05T14:12:53Z
dc.date.available2014-05-20T13:46:00Z
dc.date.available2022-10-05T14:12:53Z
dc.date.created2014-05-20T13:46:00Z
dc.date.issued2011-01-01
dc.identifierArchives of Oral Biology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 56, n. 1, p. 41-47, 2011.
dc.identifier0003-9969
dc.identifierhttp://hdl.handle.net/11449/16238
dc.identifier10.1016/j.archoralbio.2010.08.011
dc.identifierWOS:000286548400006
dc.identifier2640929291808415
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3891295
dc.description.abstractObjective: In this study we have assessed the renal and cardiac consequences of ligature-induced periodontitis in both normotensive and nitric oxide (NO)-deficient (L-NAME-treated) hypertensive rats.Materials and methods: Oral L-NAME (or water) treatment was started two weeks prior to induction of periodontitis. Rats were sacrificed 3, 7 or 14 days after ligature placement, and alveolar bone loss was evaluated radiographically. Thiobarbituric reactive species (TBARS; a lipid peroxidation index), protein nitrotyrosine (NT; a marker of protein nitration) and myeloperoxidase activity (MPO; a neutrophil marker) were determined in the heart and kidney.Results: In NO-deficient hypertensive rats, periodontitis-induced alveolar bone loss was significantly diminished. In addition, periodontitis-induced cardiac NT elevation was completely prevented by L-NAME treatment. on the other hand L-NAME treatment enhanced MPO production in both heart and kidneys of rats with periodontitis. No changes due to periodontitis were observed in cardiac or renal TBARS content.Conclusions: In addition to mediating alveolar bone loss, NO contributes to systemic effects of periodontitis in the heart and kidney. (C) 2010 Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relationArchives of Oral Biology
dc.relation2.050
dc.relation0,752
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPeriodontitis
dc.subjectNitric oxide
dc.subjectNeutrophils
dc.subjectNitrotyrosine
dc.subjectLipid peroxidation
dc.subjectHeart
dc.subjectKidney
dc.titleLocal and cardiorenal effects of periodontitis in nitric oxide-deficient hypertensive rats
dc.typeArtigo


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