dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2013-09-30T18:29:24Z | |
dc.date.accessioned | 2014-05-20T13:43:15Z | |
dc.date.accessioned | 2022-10-05T14:05:24Z | |
dc.date.available | 2013-09-30T18:29:24Z | |
dc.date.available | 2014-05-20T13:43:15Z | |
dc.date.available | 2022-10-05T14:05:24Z | |
dc.date.created | 2013-09-30T18:29:24Z | |
dc.date.created | 2014-05-20T13:43:15Z | |
dc.date.issued | 2009-09-01 | |
dc.identifier | Journal of Clinical Periodontology. Malden: Wiley-blackwell Publishing, Inc, v. 36, n. 9, p. 775-783, 2009. | |
dc.identifier | 0303-6979 | |
dc.identifier | http://hdl.handle.net/11449/15064 | |
dc.identifier | 10.1111/j.1600-051X.2009.01450.x | |
dc.identifier | WOS:000268924600008 | |
dc.identifier | 8399870097572073 | |
dc.identifier | 4068921369233125 | |
dc.identifier | 9831236034935598 | |
dc.identifier | 0169955363968097 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3890349 | |
dc.description.abstract | AimThis study histologically analysed the effect of autogenous platelet-rich plasma (PRP), prepared according to a new semiautomatic system, on healing of autogenous bone (AB) grafts placed in surgically created critical-size defects (CSD) in rabbit calvaria.Material and MethodsSixty rabbits were divided into three groups: C, AB and AB/PRP. A CSD was created in the calvarium of each animal. In Group C (control), the defect was filled by blood clot only. In Group AB (autogenous bone graft), the defect was filled with particulate autogenous bone. In Group AB/PRP (autogenous bone graft with platelet-rich plasma), it was filled with particulate autogenous bone combined with PRP. All groups were divided into subgroups (n=10) and euthanized at 4 or 12 weeks post-operatively. Histometric and histologic analyses were performed. Data were statistically analysed (anova, t-test, p < 0.05).ResultsGroup C presented significantly less bone formation compared with Group AB and AB/PRP in both periods of analysis (p < 0.001). At 4 weeks, Group AB/PRP showed a statistically greater amount of bone formation than Group AB (64.44 +/- 15.0% versus 46.88 +/- 14.15%; p=0.0181). At 12 weeks, no statistically significant differences were observed between Groups AB and AB/PRP (75.0 +/- 8.11% versus 77.90 +/- 8.13%; p > 0.05). It is notable that the amount of new bone formation in Group AB/PRP at 4 weeks was similar to that of Group AB at 12 weeks (p > 0.05).ConclusionWithin its limitation, the present study has indicated that (i) AB and AB/PRP significantly improved bone formation and (ii) a beneficial effect of PRP was limited to an initial healing period of 4 weeks. | |
dc.language | eng | |
dc.publisher | Wiley-Blackwell Publishing, Inc | |
dc.relation | Journal of Clinical Periodontology | |
dc.relation | 4.046 | |
dc.relation | 2,079 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | bone grafting | |
dc.subject | bone regeneration | |
dc.subject | growth factors | |
dc.subject | in vivo model | |
dc.subject | platelets | |
dc.title | Effect of platelet-rich plasma on bone healing of autogenous bone grafts in critical-size defects | |
dc.type | Artigo | |