dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Universidade Estadual de Campinas (UNICAMP) | |
dc.date.accessioned | 2014-05-20T13:37:26Z | |
dc.date.accessioned | 2022-10-05T13:51:07Z | |
dc.date.available | 2014-05-20T13:37:26Z | |
dc.date.available | 2022-10-05T13:51:07Z | |
dc.date.created | 2014-05-20T13:37:26Z | |
dc.date.issued | 2009-02-01 | |
dc.identifier | Journal of Molecular Histology. Dordrecht: Springer, v. 40, n. 1, p. 1-11, 2009. | |
dc.identifier | 1567-2379 | |
dc.identifier | http://hdl.handle.net/11449/12953 | |
dc.identifier | 10.1007/s10735-008-9206-x | |
dc.identifier | WOS:000264485300001 | |
dc.identifier | 7263490918934874 | |
dc.identifier | 3278528112652257 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3888655 | |
dc.description.abstract | Activity of metalloproteinases 2 and 9 (MMP-2 and 9) during promotion and progression of rat liver carcinogenesis was investigated in a modified resistant hepatocyte model. Development of preneoplastic liver lesions positive for glutathione S-transferase 7-7-(GST-P 7-7-positive PNL) and tumors besides hepatocytes positive for proliferating cell nuclear antigen (PCNA) were quantified and compared to MMP-2 and-9 activity using gelatin zymography. Marked increases in GST-P 7-7-positive PNL development, PCNA labeling indices, MMP-2 (pro, intermediate and active forms) and pro-MMP-9 activity were observed after proliferative stimulus induced by 2-acetylaminofluorene (2-AAF) exposure cycles. After 2-AAF withdrawal, increase in MMP-2 activity was detected only in neoplastic mixed lesions, whereas active MMP-9 was increased in both PLN and neoplastic tissues. Our findings suggest that MMP-2 may be associated with proliferative events induced by 2-AAF rather than with selective growth of PNL and that MMP-9 could be associated with progression of PNL and neoplastic mixed lesions. | |
dc.language | eng | |
dc.publisher | Springer | |
dc.relation | Journal of Molecular Histology | |
dc.relation | 2.412 | |
dc.relation | 0,981 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Rat liver carcinogenesis | |
dc.subject | Resistant hepatocyte model | |
dc.subject | Metalloproteinases | |
dc.subject | Preneoplastic and neoplastic lesions | |
dc.title | Metalloproteinases 2 and-9 activity during promotion and progression stages of rat liver carcinogenesis | |
dc.type | Artigo | |