Morphologic changes in the urethral epithelium in an ethanol-drinking rat strain (UChA and UChB)

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal de Minas Gerais (UFMG)
dc.contributorUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2014-05-20T13:37:04Z
dc.date.accessioned2022-10-05T13:50:24Z
dc.date.available2014-05-20T13:37:04Z
dc.date.available2022-10-05T13:50:24Z
dc.date.created2014-05-20T13:37:04Z
dc.date.issued2007-01-01
dc.identifierMicron. Oxford: Pergamon-Elsevier B.V., v. 38, n. 7, p. 734-746, 2007.
dc.identifier0968-4328
dc.identifierhttp://hdl.handle.net/11449/12798
dc.identifier10.1016/j.micron.2007.05.008
dc.identifierWOS:000249320300006
dc.identifier8727897080522289
dc.identifier1739564105219382
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3888564
dc.description.abstractThe extreme use of ethanol causes metabolic and pathologic changes in testes and urogenital system in different animal species. The enzyme alcohol dehydrogenase (ADH) catalyses the conversion of ethanol into carcinogenic metabolite acetaldehyde which is partly excreted into the urine. However, papers relating the chronic ethanol consumption to the urethral morphology are unknown. This work evaluates the toxic effect of the chronic ethanol ingestion on the urethral epithelium of UChA and UChB rats. Conventional techniques of histology, histochemistry, immunohistochemistry and ultrastructural analysis were used. The analysis showed the presence of lipid drops and intercellular spaces in the epithelial cells in the urethra of UChA and UChB rats compared to control rats. Urethral neuroendocrine cell were observed and characterized for presenting vesicles containing electron-dense granules associated with nervous fibers. We conclude that the chronic consumption of ethanol induces the presence lipid drops in the epithelial cells of the urethra of UChA and UChB rats. The NE cells of the urethra of UChA and UChB rats did not show alterations under chronic effect of the ethanol. (C) 2007 Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationMicron
dc.relation1.728
dc.relation0,624
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjecturethra
dc.subjectUCh rats
dc.subjectexperimental alcoholism
dc.subjectneuroendocrine cell
dc.subjectmorphology
dc.titleMorphologic changes in the urethral epithelium in an ethanol-drinking rat strain (UChA and UChB)
dc.typeArtigo


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