Promotion of hepatocarcinogenesis by hexachlorobenzene in energy-restricted rats

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Estadual de Londrina (UEL)
dc.date.accessioned2014-05-20T13:37:03Z
dc.date.accessioned2022-10-05T13:50:18Z
dc.date.available2014-05-20T13:37:03Z
dc.date.available2022-10-05T13:50:18Z
dc.date.created2014-05-20T13:37:03Z
dc.date.issued2000-04-28
dc.identifierCancer Letters. Clare: Elsevier Sci Ireland Ltd, v. 152, n. 1, p. 37-44, 2000.
dc.identifier0304-3835
dc.identifierhttp://hdl.handle.net/11449/12782
dc.identifier10.1016/S0304-3835(99)00432-2
dc.identifierWOS:000166661200006
dc.identifier3278528112652257
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3888554
dc.description.abstractThe interaction between dietary energy restriction and low dose of the fungicide hexachlorobenzene (HCB) was evaluated in a rat liver medium-term bioassay for carcinogenesis. Male Wistar rats were fed a control or a 50% energy-restricted diet, both added or not with 50 ppm HCB, for 6 weeks. HCB exposure or energy restriction separately did not exert any influence on the development of glutathione S-transferase placental form (GST-P+) foci of hepatocytes. Simultaneous HCB exposure and energy restriction induced a significant increase in liver centrilobular hypertrophy and GST-P+ foci development. Our findings suggest that energy restriction increases liver response to low dose of HCB, unmasking the promoting potential of this fungicide. (C) 2000 Elsevier B.V. Ireland Ltd. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationCancer Letters
dc.relation6.491
dc.relation2,350
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectenergy restriction
dc.subjectcarcinogenesis
dc.subjecthexachlorobenzene
dc.subjectmedium-term bioassay
dc.subjectliver GST-P-positive foci
dc.titlePromotion of hepatocarcinogenesis by hexachlorobenzene in energy-restricted rats
dc.typeArtigo


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