Artigo
Antioxidant supplementation and premature rupture of the membranes: a planned secondary analysis
Date
2008-10-01Registration in:
American Journal of Obstetrics and Gynecology. New York: Mosby-elsevier, v. 199, n. 4, p. 8, 2008.
0002-9378
10.1016/j.ajog.2008.07.011
WOS:000260045700042
6758680388835078
0000-0002-9227-832X
Author
Univ Cincinnati
Universidade Federal de Pernambuco (UFPE)
Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (Unesp)
Universidade Federal do Rio Grande do Sul (UFRGS)
RTI Int
NICHHD
Abstract
OBJECTIVE: The purpose of this study was to determine if antioxidant supplementation during pregnancy reduces the incidence of premature rupture of the membranes (PROM).STUDY DESIGN: A placebo-controlled, double-blind trial was conducted. PROM and preterm PROM (PPROM) were planned secondary outcomes of the trial. Women between 12(0/7) and 19(6/7) weeks of gestation and diagnosed to have chronic hypertension or a prior history of preeclampsia were randomized to daily treatment with both vitamin C (1000 mg) and E (400 IU) or placebo.RESULTS: Outcome data for PROM were available for 697 of 739 patients. The rates of PROM (37/349 [10.6%] vs 19/348 [5.5%]; adjusted risk ratio [RR] 1.89 [95.42% CI, 1.11-3.23]; P = .015), and PPROM (16/349 [4.6%] vs 6/348 [1.7%]; RR 2.68 [1.07-6.71]; P = .025) were increased in the antioxidant group.CONCLUSION: Contrary to expectations, vitamins C and E supplementation in this dose combination may be associated with an increased risk of PROM and PPROM.