Polymorphisms in the AR and PSA Genes as Markers of Susceptibility and Aggressiveness in Prostate Cancer

dc.contributorUniversidade Estadual de Londrina (UEL)
dc.contributorLondrina Hosp Canc
dc.contributorHlth Sci Ctr
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:34:26Z
dc.date.accessioned2022-10-05T13:43:23Z
dc.date.available2014-05-20T13:34:26Z
dc.date.available2022-10-05T13:43:23Z
dc.date.created2014-05-20T13:34:26Z
dc.date.issued2010-11-01
dc.identifierCancer Investigation. Philadelphia: Taylor & Francis Inc, v. 28, n. 9, p. 917-924, 2010.
dc.identifier0735-7907
dc.identifierhttp://hdl.handle.net/11449/11801
dc.identifier10.3109/07357907.2010.483509
dc.identifierWOS:000282753800005
dc.identifier2259986546265579
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3887739
dc.description.abstractThe study of genes involved in androgen pathway can contribute to a better knowledge of prostate cancer. Our aim was to examine if polymorphisms in prostate-specific antigen (PSA) and androgen receptor (AR) genes were involved in prostate cancer risk and aggressiveness. Genotypes were determined by PCR-RFLP (PSA) or using a 377 ABI DNA Sequencer (AR). PSA(G/G) genotype (OR = 1.78, 95% CI = 1.06-2.99) and AR short CAG repeats (OR = 1.89, 95% CI = 1.21-2.96) increased risk for prostate cancer and were related with tumor aggressiveness. About 38.3% of tumors showed microsatellite instability. In conclusion, polymorphisms in these genes may be indicated as potential biomarkers for prostate cancer.
dc.languageeng
dc.publisherTaylor & Francis Inc
dc.relationCancer Investigation
dc.relation2.053
dc.relation0,858
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAR gene
dc.subjectGleason score
dc.subjectHistopathological parameters
dc.subjectPolymorphisms
dc.subjectProstate Cancer
dc.subjectPSA gene
dc.titlePolymorphisms in the AR and PSA Genes as Markers of Susceptibility and Aggressiveness in Prostate Cancer
dc.typeArtigo


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