Vibrational and Thermal Properties of Crystalline Topiramate

Artigo

Fecha

2008-01-01

Registro en:

Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 19, n. 8, p. 1607-1613, 2008.

0103-5053

http://hdl.handle.net/11449/8769

10.1590/S0103-50532008000800022

S0103-50532008000800022

WOS:000261658800022

S0103-50532008000800022.pdf

1159480346990821

0000-0001-6086-5303

http://repositorioslatinoamericanos.uchile.cl/handle/2250/3885295

Autor

Universidade Federal do Ceará (UFC)

Univ Reg Cariri

Universidade Estadual Paulista (Unesp)

Universidade Estadual de Campinas (UNICAMP)

Institución

Universidade Paulista Júlio de Mesquita Filho (Brasil)

Resumen

Topiramate, a powerful anticonvulsant drug, was investigated by X-ray diffractometry, FT-Raman, FT-IR, TGA and DTA techniques as well as by DFT calculations. From this study it was possible to tentatively assign most of the normal vibrational modes of the crystal. Thermal analysis from room temperature to 900 degrees C shows that the material does not present any structural phase transition and that the decomposition occurs in a two-step exothermic process.

Materias

organic crystals

vibrational spectra

X-ray diffraction

thermodynamic properties

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