Synthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:46Z
dc.date.accessioned2022-10-05T13:14:48Z
dc.date.available2014-05-20T13:24:46Z
dc.date.available2022-10-05T13:14:48Z
dc.date.created2014-05-20T13:24:46Z
dc.date.issued2009-09-01
dc.identifierMolecules. Basel: Molecular Diversity Preservation International-mdpi, v. 14, n. 9, p. 3187-3197, 2009.
dc.identifier1420-3049
dc.identifierhttp://hdl.handle.net/11449/7781
dc.identifier10.3390/molecules14093187
dc.identifierWOS:000270201900007
dc.identifierWOS000270201900007.pdf
dc.identifier9734333607975413
dc.identifier1066743423929093
dc.identifier0000-0003-4141-0455
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3884559
dc.description.abstractThe compound 1-(2,6-dichlorophenyl)indolin-2-one (1), planned as a pro-drug of diclofenac (2), was easily synthesized in 94% yield by an intramolecular reaction in the presence of coupling agent (i.e., EDC). Compound 1 showed anti-inflammatory and analgesic activity without gastro-ulcerogenic effects. The chemical and enzymatic hydrolysis profile of the lactam derivative 1 does not indicate conversion to diclofenac (2). This compound is a new non-ulcerogenic prototype for treatment of chronic inflammatory diseases.
dc.languageeng
dc.publisherMolecular Diversity Preservation International-mdpi
dc.relationMolecules
dc.relation3.098
dc.relation0,855
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectindolinone
dc.subjectpro-drug
dc.subjectanti-inflammatory
dc.subjecthydrolysis
dc.subjectdiclofenac
dc.titleSynthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties
dc.typeArtigo


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