TNFa-e microsatellite, HLA-DRB1 and-DQB1 alleles and haplotypes in Brazilian patients presenting recently diagnosed type 1 diabetes mellitus

dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:33Z
dc.date.accessioned2022-10-05T13:14:07Z
dc.date.available2014-05-20T13:24:33Z
dc.date.available2022-10-05T13:14:07Z
dc.date.created2014-05-20T13:24:33Z
dc.date.issued2006-01-01
dc.identifierImmunology of Diabetes Iv: Progress In Our Understanding. Oxford: Blackwell Publishing, v. 1079, p. 300-304, 2006.
dc.identifier0077-8923
dc.identifierhttp://hdl.handle.net/11449/7654
dc.identifier10.1196/annals.1375.045
dc.identifierWOS:000243126100045
dc.identifier1768025290373669
dc.identifier0000-0003-1740-7360
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3884476
dc.description.abstractTNF microsatellite and HLA class II polymorphisms were studied in 28 recently diagnosed Brazilian patients presenting type 1 diabetes mellitus (T1DM) and in 120 healthy controls. TNFa-e and HLA-DRB1/DQB1 alleles were identified using sets of sequence-specific primers. Compared to controls, the DRB1* 03 and DQBI*02 allele groups, TNFa1 allele, and the TNFa4-b5-c1-d4-e3 and TNFa10-b5-c1-d4-e3 haplotypes were overrepresented in patients. TNF microsatellite together with HLA polymorphisms is associated with type 1 diabetes in Brazilian patients, corroborating the participation of the MHC genes in disease susceptibility.
dc.languageeng
dc.publisherBlackwell Publishing
dc.relationImmunology of Diabetes Iv: Progress In Our Understanding
dc.relation4.277
dc.relation2,108
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjecttype 1 diabetes mellitus
dc.subjectpolymorphism
dc.subjectTNF microsatellite
dc.subjectHLA
dc.titleTNFa-e microsatellite, HLA-DRB1 and-DQB1 alleles and haplotypes in Brazilian patients presenting recently diagnosed type 1 diabetes mellitus
dc.typeArtigo


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