Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:24:26Z
dc.date.accessioned2022-10-05T13:13:40Z
dc.date.available2014-05-20T13:24:26Z
dc.date.available2022-10-05T13:13:40Z
dc.date.created2014-05-20T13:24:26Z
dc.date.issued2001-06-01
dc.identifierArchiv Der Pharmazie. Berlin: Wiley-v C H Verlag Gmbh, v. 334, n. 6, p. 189-193, 2001.
dc.identifier0365-6233
dc.identifierhttp://hdl.handle.net/11449/7577
dc.identifier10.1002/1521-4184(200106)334:6<189
dc.identifierWOS:000169717500002
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3884417
dc.description.abstractWith the objective of obtaining slow-acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium Il(tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.
dc.languagedeu
dc.publisherWiley-Blackwell
dc.relationArchiv Der Pharmazie
dc.relation2.288
dc.relation0,413
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectpotential tuberculostatic agent
dc.subjectisoniazid
dc.subjectprodrug
dc.subjectmicelle-forming polymer
dc.subjectco-polymer poly(ethylene glycol)-poly(aspartic acid)
dc.titlePotential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid
dc.typeArtigo


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