dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:23:58Z
dc.date.accessioned2022-10-05T13:12:27Z
dc.date.available2014-05-20T13:23:58Z
dc.date.available2022-10-05T13:12:27Z
dc.date.created2014-05-20T13:23:58Z
dc.date.issued2009-01-01
dc.identifierJournal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 20, n. 3, p. 437-444, 2009.
dc.identifier0103-5053
dc.identifierhttp://hdl.handle.net/11449/7335
dc.identifier10.1590/S0103-50532009000300005
dc.identifierS0103-50532009000300005
dc.identifierWOS:000266403300004
dc.identifierS0103-50532009000300005.pdf
dc.identifier3300223970814448
dc.identifier7927677053650819
dc.identifier0000-0002-0057-7964
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3884265
dc.description.abstractThe 1,2,4-triazolyl-bridged polynuclear complexes [{PdCl(2)(mu-Htrz)}(n)] (1) and [{PdBr(2)(mu-Htrz)}(n)] (2) have been obtained in this work. Compound 1 is prepared by the displacement of acetonitrile from [PdCl(2)(MeCN)(2)] by 1,2,4-triazole (Htrz). Further addition of potassium bromide to the reaction medium afforded complex 2. The new complexes have been isolated, purified and characterized by means of elemental analysis, IR and UV-visible electronic spectroscopies and thermogravimetric (TG) curves. The experimental data suggested that, in both cases, the coordination of 1,2,4-Htrz takes place through the N(2) and N(4) atoms, bridging the palladium centers. The square-planar coordination polyhedron of palladium(II) is determined by two nitrogen atoms from the triazole ligands, while the other two coordination positions are occupied by the chloro (1) or bromo (2) ligands. TG curves indicated that the nature of the anionic ligand does not affect significantly the thermal stability of 1 and 2. The final products of the thermal decompositions were identified as metallic palladium by X-ray powder diffractometry. Preliminary tests involving the evaluation of the effects of compounds 1, 2 and Htrz on H(2)O(2) and NO production in cultures of peritoneal macrophages from BALB/c mice were carried out in vitro.
dc.languageeng
dc.publisherSoc Brasileira Quimica
dc.relationJournal of the Brazilian Chemical Society
dc.relation1.444
dc.relation0,357
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectpalladium(II) complexes
dc.subject1,2,4-triazole
dc.subjectmacrophages
dc.subjectnitric oxide
dc.subjecthydrogen peroxide
dc.titleImmunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophages
dc.typeArtigo


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