Artigo
Altered Ex Vivo Expression of Caspase 8, Caspase 9, and Bcl-2 Is Associated with T-Cell Hyporeactivity in Patients with Paracoccidioidomycosis
Fecha
2009-06-01Registro en:
Clinical and Vaccine Immunology. Washington: Amer Soc Microbiology, v. 16, n. 6, p. 953-955, 2009.
1556-6811
10.1128/CVI.00071-09
WOS:000266638900025
WOS000266638900025.pdf
0000-0002-8059-0826
Autor
Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
Fiocruz MS
Resumen
To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis.