dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:23:41Z
dc.date.accessioned2022-10-05T13:11:45Z
dc.date.available2014-05-20T13:23:41Z
dc.date.available2022-10-05T13:11:45Z
dc.date.created2014-05-20T13:23:41Z
dc.date.issued2010-12-01
dc.identifierLatin American Journal of Pharmacy. La Plata: Colegio Farmaceuticos Provincia de Buenos Aires, v. 29, n. 8, p. 1419-1424, 2010.
dc.identifier0326-2383
dc.identifierhttp://hdl.handle.net/11449/7193
dc.identifierWOS:000288060000022
dc.identifier3242858535763793
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3884179
dc.description.abstractOxidized Low-Density Lipoproteins (oxLDL) and autoantibodies against oxLDL are important in the development of atherosclerotic lesions. Statins are efficacious in the control of dyslipidemia and prevention of atherosclerosis; however, many questions concerning the mechanism of action of such drugs remain unknown. This work investigated the effect of simvastatin on generation of autoantibodies against oxLDL and development of atherosclerosis in rabbits. The animals were divided into three groups: control, hypercholesterolemic, and hypercholesterolemic simvastatin (3.0 mg simvastatin/ kg body weight). Concentrations of autoantibodies against oxLDL were determined on days 0,30 and 60 of the experiment and the atherosclerotic lesions were evaluated at the end of the study. Simvastatin reduced intimal proliferation in the thoracic region, prevented arterial calcification and inhibited the generation of autoantibodies against oxLDL. In conclusion, daily administration of simvastatin slows down atherosclerotic lesion development in rabbits with induced hypercholesterolemia and inhibition on generation of autoantibodies against oxLDL contributes to the cardioprotective effect observed.
dc.languageeng
dc.publisherColegio Farmaceuticos Provincia de Buenos Aires
dc.relationLatin American Journal of Pharmacy
dc.relation0.401
dc.relation0,152
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAtherosclerosis
dc.subjectAutoantibodies against oxidized LDL
dc.subjectSimvastatin
dc.titleEffect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
dc.typeArtigo


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