dc.contributorAarhus University (AU)
dc.contributorUniv Birmingham
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:18:03Z
dc.date.accessioned2022-10-05T12:48:24Z
dc.date.available2014-05-20T13:18:03Z
dc.date.available2022-10-05T12:48:24Z
dc.date.created2014-05-20T13:18:03Z
dc.date.issued2007-11-01
dc.identifierComparative Biochemistry and Physiology A-molecular & Integrative Physiology. New York: Elsevier B.V., v. 148, n. 3, p. 510-520, 2007.
dc.identifier1095-6433
dc.identifierhttp://hdl.handle.net/11449/4298
dc.identifier10.1016/j.cbpa.2007.06.420
dc.identifierWOS:000250656100004
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3881835
dc.description.abstractThe present study investigates adrenergic regulation of the systemic and pulmonary circulations of the anaesthetised South American rattlesnake, Crotalus durissus. Haemodynamic measurements were made following bolus injections of adrenaline and adrenergic antagonists administered through a systemic arterial catheter. Adrenaline caused a marked systemic vasoconstriction that was abolished by phentolamine, indicating this response was mediated through alpha-adrenergic receptors. Injection of phentolamine gave rise to a pronounced vasodilatation (systemic conductance (G(sys)) more than doubled), while injection of propranolol caused a systemic vasoconstriction, pointing to a potent alpha-adrenergic, and a weaker beta-adrenergic tone in the systemic vasculature of Crotalus. Overall, the pulmonary vasculature was far less responsive to adrenergic stimulation than the systemic circulation. Adrenaline caused a small but non-significant pulmonary vasodilatation and there was tendency of reducing this dilatation after either phentolamine or propranolol. Injection of phentolamine increased pulmonary conductance (G(pul)), while injection of propranolol produced a small pulmonary constriction, indicating that alpha-adrenergic and beta-adrenergic receptors contribute to a basal regulation of the pulmonary vasculature. Our results suggest adrenergic regulation of the systemic vasculature, rather than the pultrionary, may be an important factor in the development of intracardiac shunts. (c) 2007 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationComparative Biochemistry and Physiology A-molecular & Integrative Physiology
dc.relation2.258
dc.relation0,836
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectreptile
dc.subjectsnake
dc.subjectcardiovascular regulation
dc.subjectadrenaline
dc.subjectadrenergic stimulation
dc.subjectpulmonary circulation
dc.subjectsystemic circulation
dc.titleThe adrenergic regulation of the cardiovascular system in the South American rattlesnake, Crotalus durissus
dc.typeArtigo


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