dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:14:16Z | |
dc.date.accessioned | 2022-10-05T12:33:11Z | |
dc.date.available | 2014-05-20T13:14:16Z | |
dc.date.available | 2022-10-05T12:33:11Z | |
dc.date.created | 2014-05-20T13:14:16Z | |
dc.date.issued | 2008-07-01 | |
dc.identifier | American Journal of Veterinary Research. Schaumburg: Amer Veterinary Medical Assoc, v. 69, n. 7, p. 854-860, 2008. | |
dc.identifier | 0002-9645 | |
dc.identifier | http://hdl.handle.net/11449/1797 | |
dc.identifier | 10.2460/ajvr.69.7.854 | |
dc.identifier | WOS:000257295000002 | |
dc.identifier | 4473260410099623 | |
dc.identifier | 0000-0001-5312-9076 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3880035 | |
dc.description.abstract | Objective-To evaluate analgesic effects of epidurally administered neostigmine alone or in combination with morphine in dogs after ovariohysterectomy.Animals-40 healthy bitches.Procedures-After acepromazine premedication, anesthesia was induced. Dogs randomly received 1 of the following 4 epidural treatments 30 minutes before ovariohysterectomy (n = 10/group): saline (0.9% NaCl) solution (control), morphine (0.1 mg/kg), neostigmine (10 pg/kg), or morphine-neostigmine (0.1 mg/kg and 10 pg/kg, respectively). Analgesia was assessed for 24 hours after surgery by use of a visual analogue.scale (VAS; scale of 0 to 10) or numeric descriptive scale (NDS; scale of 0 to 24) and by the need for supplemental analgesia (morphine [0.5 mg/kg, IM] administered when VAS was >= 4 or NDS was >= 8).Results-Significantly more control dogs (n = 8) received supplemental analgesia, compared with the number of neostigmine-treated dogs (1); no dogs in the remaining groups received supplemental analgesia. Compared with values for the control dogs, the NDS scores were lower for morphine-neostigmine-treated dogs (from 2 to 6 hours and at 12 hours) and for morphine-treated dogs (all time points). The NDS scores were lower for morphine-treated dogs at 3, 12, and 24 hours, compared with values for neostigmine-treated dogs. The VAS was less sensitive than the NDS for detecting differences among groups.Conclusions and Clinical Relevance-Epidurally administered neostigmine reduced the use of supplemental analgesia after ovariohysterectorny in dogs. However, analgesic effects were less pronounced than for epidurally administered morphine or morphine-neostigmine. Adding neostigmine to epidurally administered morphine did not potentiate opioid-induced analgesia. | |
dc.language | eng | |
dc.publisher | Amer Veterinary Medical Assoc | |
dc.relation | American Journal of Veterinary Research | |
dc.relation | 0.833 | |
dc.relation | 0,567 | |
dc.rights | Acesso restrito | |
dc.source | Web of Science | |
dc.title | Postoperative analgesic effects of epidural administration of neostigmine alone or in combination with morphine in ovariohysterectomized dogs | |
dc.type | Artigo | |