Preliminary cryocrystallography analysis of an eumenine mastoparan toxin isolated from the venom of the wasp Anterhynchium flavomarginatum micado

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorInstituto Butantan
dc.contributorFEB
dc.contributorCtr Univ Votuporanga
dc.date.accessioned2014-05-20T13:12:47Z
dc.date.accessioned2022-10-05T12:25:21Z
dc.date.available2014-05-20T13:12:47Z
dc.date.available2022-10-05T12:25:21Z
dc.date.created2014-05-20T13:12:47Z
dc.date.issued2001-02-09
dc.identifierBiochimica Et Biophysica Acta-protein Structure and Molecular Enzymology. Amsterdam: Elsevier B.V., v. 1545, n. 1-2, p. 372-376, 2001.
dc.identifier0167-4838
dc.identifierhttp://hdl.handle.net/11449/714
dc.identifier10.1016/S0167-4838(00)00192-8
dc.identifierWOS:000167072700038
dc.identifier2406867656111498
dc.identifier2835029061696580
dc.identifier2901888624506535
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3879147
dc.description.abstractMastoparans are tetradecapeptides found to be the major component of vespid venoms. These peptides present a wide spectrum of biological activities, such as mast cell degranulation, hemolytic activity and also reveals antimicrobial activity. A mastoparan toxin isolated from the venom of Anterhynchium flavomarginatum micado has been crystallized. At room temperature these crystals diffracted to 2.8 Angstrom resolution. However, upon cooling to cryogenic temperature around 85 K, the original resolution limit could be improved to 2.0 Angstrom. Crystals were determined to belong to the space group P3(1) (P3(2)). This is the first mastoparan to be crystallized and it will provide further insights in the conformational significance of mastoparan toxins, with respect to their potency and activity in G protein regulation. (C) 3001 Elsevier B.V. B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationBiochimica Et Biophysica Acta-protein Structure and Molecular Enzymology
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectmastoparan
dc.subjectcryocrystallography
dc.subjectsynchrotron
dc.subjectwasp
dc.titlePreliminary cryocrystallography analysis of an eumenine mastoparan toxin isolated from the venom of the wasp Anterhynchium flavomarginatum micado
dc.typeArtigo


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