Desenvolvimento e caracterização de nanocápsulas de poli (L-lactídeo) contendo benzocaína

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.contributorUniversidade Federal do ABC (UFABC)
dc.date.accessioned2014-05-20T13:12:10Z
dc.date.accessioned2022-10-05T12:21:53Z
dc.date.available2014-05-20T13:12:10Z
dc.date.available2022-10-05T12:21:53Z
dc.date.created2014-05-20T13:12:10Z
dc.date.issued2010-01-01
dc.identifierQuímica Nova. Sociedade Brasileira de Química, v. 33, n. 1, p. 65-69, 2010.
dc.identifier0100-4042
dc.identifierhttp://hdl.handle.net/11449/156
dc.identifier10.1590/S0100-40422010000100013
dc.identifierS0100-40422010000100013
dc.identifierWOS:000274726800013
dc.identifierS0100-40422010000100013.pdf
dc.identifier1509480515046572
dc.identifier2188736885721242
dc.identifier0000-0002-2042-018X
dc.identifier0000-0002-0284-5782
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3878767
dc.description.abstractIn this paper we describe the preparation poly (L-lactide) (PLA) nanocapsules as a drug delivery system for the local anesthetic benzocaine. The characterization and in vitro release properties of the system were investigated. The characterization results showed a polydispersity index of 0.14, an average diameter of 190.1± 3 nm, zeta potential of -38.5 mV and an entrapment efficiency of 73%. The release profile of Benzocaine loaded in PLA nanocapsules showed a significant different behavior than that of the pure anesthetic in solution. This study is important to characterize a drug release system using benzocaine for application in pain treatment.
dc.languagepor
dc.publisherSociedade Brasileira de Química
dc.relationQuímica Nova
dc.relation0.646
dc.relation0,255
dc.rightsAcesso aberto
dc.sourceSciELO
dc.subjectlocal anesthesic
dc.subjectPLA nanocapsules
dc.subjectdrug release
dc.titleDesenvolvimento e caracterização de nanocápsulas de poli (L-lactídeo) contendo benzocaína
dc.typeArtigo


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