Variantes do P21/WAF1 e da ciclina D1 e carcinoma de células escamosas de boca

dc.contributorRicardo Alves de Mesquita
dc.contributorRicardo Santiago Gomez
dc.contributorAnilton Cesar Vasconcelos
dc.contributorSERGIO NEVES DRUMMOND
dc.creatorCarolina Cavalieri Gomes
dc.date.accessioned2019-08-12T17:31:07Z
dc.date.accessioned2022-10-04T00:38:15Z
dc.date.available2019-08-12T17:31:07Z
dc.date.available2022-10-04T00:38:15Z
dc.date.created2019-08-12T17:31:07Z
dc.date.issued2007-02-15
dc.identifierhttp://hdl.handle.net/1843/ZMRO-6ZXMRY
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3835455
dc.description.abstractGenetic factors are known to be involved in oral squamous cell carcinoma (OSCC) development. We evaluated a possible association between CCND1 G870A and P21 C98A polymorphisms in OSCC, as well as the impact of the genotypes on protein immunoexpression. No statistical association between CCND1 and/or P21 genotypes in OSCC was demonstrated, although we found that people harboring the combined presence of at least one variant allele of both genes showed a 1.8 times more chance of developing OSCC compared to the referent genotype. OSCC tumours from individuals with P21 heterozygous genotype showed a significantly higher immunopositivity than tumours from wild-type individuals, demonstrating that P21 protein expression in OSCC is affected by P21/WAF1 genotype.
dc.publisherUniversidade Federal de Minas Gerais
dc.publisherUFMG
dc.rightsAcesso Aberto
dc.subjectCâncer bucal
dc.subjectCiclo celular
dc.subjectPolimorfismos genéticos
dc.titleVariantes do P21/WAF1 e da ciclina D1 e carcinoma de células escamosas de boca
dc.typeDissertação de Mestrado


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