dc.contributor | Ricardo Alves de Mesquita | |
dc.contributor | Ricardo Santiago Gomez | |
dc.contributor | Anilton Cesar Vasconcelos | |
dc.contributor | SERGIO NEVES DRUMMOND | |
dc.creator | Carolina Cavalieri Gomes | |
dc.date.accessioned | 2019-08-12T17:31:07Z | |
dc.date.accessioned | 2022-10-04T00:38:15Z | |
dc.date.available | 2019-08-12T17:31:07Z | |
dc.date.available | 2022-10-04T00:38:15Z | |
dc.date.created | 2019-08-12T17:31:07Z | |
dc.date.issued | 2007-02-15 | |
dc.identifier | http://hdl.handle.net/1843/ZMRO-6ZXMRY | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3835455 | |
dc.description.abstract | Genetic factors are known to be involved in oral squamous cell carcinoma (OSCC) development. We evaluated a possible association between CCND1 G870A and P21 C98A polymorphisms in OSCC, as well as the impact of the genotypes on protein immunoexpression. No statistical association between CCND1 and/or P21 genotypes in OSCC was demonstrated, although we found that people harboring the combined presence of at least one variant allele of both genes showed a 1.8 times more chance of developing OSCC compared to the referent genotype. OSCC tumours from individuals with P21 heterozygous genotype showed a significantly higher immunopositivity than tumours from wild-type individuals, demonstrating that P21 protein expression in OSCC is affected by P21/WAF1 genotype. | |
dc.publisher | Universidade Federal de Minas Gerais | |
dc.publisher | UFMG | |
dc.rights | Acesso Aberto | |
dc.subject | Câncer bucal | |
dc.subject | Ciclo celular | |
dc.subject | Polimorfismos genéticos | |
dc.title | Variantes do P21/WAF1 e da ciclina D1 e carcinoma de células escamosas de boca | |
dc.type | Dissertação de Mestrado | |