dc.contributor | Milene Alvarenga Rachid | |
dc.contributor | http://lattes.cnpq.br/3623617560642333 | |
dc.contributor | Vitor Márcio Ribeiro | |
dc.contributor | Rubens Antônio Carneiro | |
dc.contributor | Thiago Henrique Caldeira de Oliveira | |
dc.creator | Luiza Cioglia Dias Lima | |
dc.date.accessioned | 2022-06-06T14:56:07Z | |
dc.date.accessioned | 2022-10-03T23:01:25Z | |
dc.date.available | 2022-06-06T14:56:07Z | |
dc.date.available | 2022-10-03T23:01:25Z | |
dc.date.created | 2022-06-06T14:56:07Z | |
dc.date.issued | 2019-02-28 | |
dc.identifier | http://hdl.handle.net/1843/42272 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3815305 | |
dc.description.abstract | Hepatic encephalopathy (HE) is a neurological complication observed in hepatic failure.
HE patients may present neuropsychiatric, neuromuscular, and behavioral disorders,
which may impair quality of life and work capability. Currently, the only definitive
treatment for hepatic failure is transplantation, which highlights the need for complete
understanding of the pathophysiology and mechanisms involved in the disease, in order
to establish new therapeutic targets and supportive measures until transplantation is
available. Experimental models of HE in rodents have been widely used. It is believed
that these models provide relevant information for understanding the mechanisms
involved in the pathogenesis of the disease, as well as the development of new
therapeutic targets. Studies evaluating neurological sequelae after the development of
hepatic encephalopathy as well as its association with tissue data, inflammatory and
neurochemical profiles in later stages of the disease are scarce. Using C57BL/6 female
mice, between eight and twelve weeks age, we investigated behavioral and pathological
changes association with inflammatory and neuroprotective responses during HE that
follows hepatic failure induced by intraperitoneal injection of thioacetamide (TAA).
Mice were divided into TAA and control groups, the latter being submitted to
intraperitoneal injection of saline. TAA animals presented liver damage associated with
increased activity of neutrophils and macrophages. In addition, induced animals
demonstrated in the applied tests, anxiety-like and depression-like behavior and
morphological changes of astrocytes and microglia. This same group showed a
significant reduction in expression of proinflammatory cytokines interferon- (IFN-)
and interleukin-6 (IL-6) in the hippocampus and the brain-derived neurotrophic factor
(BNDF) in the cerebral cortex when compared to the control animals. Our results
suggest that inflammatory and neuroprotective responses disorders are associated with
behavioral deficits in murine hepatic encephalopathy. | |
dc.publisher | Universidade Federal de Minas Gerais | |
dc.publisher | Brasil | |
dc.publisher | ICB - DEPARTAMENTO DE PATOLOGIA | |
dc.publisher | Programa de Pós-Graduação em Patologia | |
dc.publisher | UFMG | |
dc.rights | Acesso Aberto | |
dc.subject | Encefalopatia hepática | |
dc.subject | Tioacetamida | |
dc.subject | Comportamento | |
dc.subject | Depressão | |
dc.subject | Ansiedade | |
dc.subject | Patologia | |
dc.subject | Inflamação | |
dc.subject | Fatores neurotróficos | |
dc.title | Aspectos comportamentais associados às alterações patológicas, inflamatórias e neuroquímicas na encefalopatia hepática experimental | |
dc.type | Dissertação | |