Brasil | Tese de Doutorado
dc.contributorFrancisco Carlos Faria Lobato
dc.contributorAndrey Pereira Lage
dc.contributorRomulo Cerqueira Leite
dc.contributorLuiz Guilherme Dias Heneine
dc.creatorPatricia Martins Parreiras
dc.date.accessioned2019-08-12T00:27:51Z
dc.date.accessioned2022-10-03T23:00:33Z
dc.date.available2019-08-12T00:27:51Z
dc.date.available2022-10-03T23:00:33Z
dc.date.created2019-08-12T00:27:51Z
dc.date.issued2003-12-17
dc.identifierhttp://hdl.handle.net/1843/BUOS-8FEJ7Z
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3815037
dc.description.abstractSixty five strains of Mycobacterium bovis were isolated from macroscopic lesions typical of tuberculosis from cattle slaughtered in slaughter house under SIF from different regions of Minas Gerais and other regions of Brazil and analyzed by the molecular techniques spoligotyping e MIRU-VNTR 12 loci. Same profiles were found in isolates from different regions of Brazil, what can be justified by the transit of the cattle in the country. Spoligotyping associated to complete epidemiologic information demonstrated to be important for the comprehension of the tuberculosis course and will collaborate with the control campaign of tuberculosis in Brazil. Spoligotyping and MIRU-VNTR analyses gave, respectively, 36 and 19 different profiles for M. bovis isolates, indicating that the 12 MIRU-VNTR loci were not good discriminators. The strain resistance to chemiotherapeutic agents was also studied. None of the isolated strains presented resistance to the main chermiotherapeutic agents applied for human tuberculosis treatment, among them the isoniazid, used for cattle tuberculosis treatment. Therefore, the results support the medication choice in the case of human patients infected by M. bovis, and add information to the veterinary field regarding the situation of isoniazid sensitivity
dc.publisherUniversidade Federal de Minas Gerais
dc.publisherUFMG
dc.rightsAcesso Aberto
dc.subjectMycobacterium bovis
dc.subjectSpoligotyping
dc.subjectMIRU-VNTR
dc.titleTipificação de Mycobacterium bovis utilizando Spoligotyping e MIRU-VNTR e avaliação da sensibilidade à quimioterápicos de estirpes isoladas em Minas Gerais e de outras regiões brasileiras
dc.typeTese de Doutorado


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