Tese
Lutzomyia (L.) longipalpis (vetor da Leishmaniose Visceral Americana): a competência vetorial à diferentes espécies de Leishmania e a diversidade da microbiota
Fecha
2018-02-27Autor
Ana Clara Araújo Machado Pires
Institución
Resumen
Studies of the interaction between Leishmania protozoans with phlebotomine vector
constitute an important field of research, since it can improve our knowledge of the
processes involved in the transmission of the parasite and the epidemiology of
Leishmaniasis. Details regarding all of the aspects between parasite-vector interaction are
desirable for a formulation of novel protozoan and vector control strategies. Some
phlebotomine species show remarkable specificity for exclusive vectors of certain
Leishmania species transmitted in nature, while other species may be experimentally
infected by more than one species of parasite. The term "Permissive Vectors" has been
created to describe the latter. It is not yet known exactly how the interaction between
Permissive Vectors with the Leishmania parasites works, but it is hypothesized that the
mechanism of adhesion within the midgut of these vectors differs from the "Natural
Vectors". The present study describes the development of five distinct species of
Leishmania - L. (Leishmania) infantum chagasi, L. (Leishmania) major, L. (Leishmania)
amazonensis, L. (Leishmania) mexicana and L. (Viannia) braziliensis - in Lutzomyia (L.)
longipalpis, considered, experimentally, a permissive vector. Different concentrations of
parasites were required for determination of vector permissibility. Our results showed
that the ability of Lu. (L.) longipalpis from being infected experimentally by Leishmania
is dose dependent and the vector proved to be competent to transmit L. (L.) major and L.
(L.) mexicana.